21st May at 15:00-16:00
Online event
in Teams
Flyer

Prof. Antti Auvinen, Tampere University
A randomised pragmatic population-based trial of prostate cancer screening (ProScreen)

The seminar will be held online (Microsoft Teams) and is open to everyone interested in cancer research. This time the webinar is organized by FICAN Mid.

Get to know the speaker: Epidemiology | Tampere universities

Join the webinar from this link: Liity kokoukseen tästä / Join the meeting now

We have shown in the ERSPC trial that PSA-based screening can reduce prostate cancer mortality, but due to extensive overdiagnosis of low-risk cases, the balance of benefits and harms is questionable. We have designed a screening protocol aimed at minimising overdiagnosis, but maintaining the mortality impact.The screening intervention consist of three tests, provided in a stepwise fashion: First PSA, for men with PSA 3ng/ml also a kallikrein panel (4Kscore) and if it exceeds 7.5%, a referral to MRI. Men with a suspicious MRI findings (PI-RADS score 3–5) are referred to targeted prostate biopsy.We have randomised 113,357 men aged 50–63 from Helsinki and Tampere metropolitan areas, with a quarter allocated to screening and the rest to the control arm.Results from the first screening round show that large majority (80%) of the screen-detected cases are high-grade cancers (ISUP grade group 2–5). Compared with the control arm, one additional high-grade cancer was detected per 200 men, while the excess of low-grade cases (grade group 1) was considerably smaller (one excess case per 800 men).