BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN BEGIN:VEVENT UID:774@biocityturku.fi DTSTART;TZID=Europe/Helsinki:20250521T150000 DTEND;TZID=Europe/Helsinki:20250521T160000 DTSTAMP:20250429T103339Z URL:https://biocityturku.fi/events/fican-science-webinar-prof-antti-auvine n/ SUMMARY:FICAN Science Webinar: Prof. Antti Auvinen DESCRIPTION:21st May at 15:00-16:00\nOnline event\nin Teams\nFlyer\n\nProf. Antti Auvinen\, Tampere University\nA randomised pragmatic population-bas ed trial of prostate cancer screening (ProScreen)\n\nThe seminar will be h eld online (Microsoft Teams) and is open to everyone interested in cancer research. This time the webinar is organized by FICAN Mid.\n\nGet to know the speaker: Epidemiology | Tampere universities\n\nJoin the webinar from this link: Liity kokoukseen tästä / Join the meeting now\n\n \;\n\nW e have shown in the ERSPC trial that PSA-based screening can reduce prosta te cancer mortality\, but due to extensive overdiagnosis of low-risk cases \, the balance of benefits and harms is questionable. We have designed a s creening protocol aimed at minimising overdiagnosis\, but maintaining the mortality impact.The screening intervention consist of three tests\, provi ded in a stepwise fashion: First PSA\, for men with PSA 3ng/ml also a kall ikrein panel (4Kscore) and if it exceeds 7.5%\, a referral to MRI. Men wit h a suspicious MRI findings (PI-RADS score 3–5) are referred to targeted prostate biopsy.We have randomised 113\,357 men aged 50–63 from Helsink i and Tampere metropolitan areas\, with a quarter allocated to screening a nd the rest to the control arm.Results from the first screening round show that large majority (80%) of the screen-detected cases are high-grade can cers (ISUP grade group 2–5). Compared with the control arm\, one additio nal high-grade cancer was detected per 200 men\, while the excess of low-g rade cases (grade group 1) was considerably smaller (one excess case per 8 00 men). ATTACH;FMTTYPE=image/jpeg:https://biocityturku.fi/wp-content/uploads/fican -science-webinar-thumbnail.jpg CATEGORIES:Other events END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20250330T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR