6^th March at 15:00
Onsite event
in ÅA Farmaci Lecture Hall, 3rd floor, BioCity

Prof. Marc Vooijs, Maastricht University, the Netherlands
Unlocking a New Regulatory Switch in NOTCH Signaling:  Deciding Between Activation and Inactivation

Host: Päivi Koskinen (paivi.koskinen@utu.fi)

Coffee, tea and buns served at 14:45.

Join us for an inspiring seminar by Prof. Marc Vooijs, whose research is focused on mechanistic insight into signal transduction by NOTCH family proteins and their context-dependent role in stem cells, cancer development and treatment response with an emphasis on tumor microenvironment and hypoxia. He has alsoestablished patient-derived 3D cell models to study therapeutic resistance mechanisms under both normal and hypoxic conditions. For more information: https://www.maastrolab.com/marc-vooijs-lab

Selected recent publications

Sánchez-Castillo A et al. Sertraline/chloroquine combination therapy to target hypoxic and immunosuppressive serine/glycine synthesis-dependent glioblastomas. Oncogenesis 13, 39, 2024. DOI: 10.1038/s41389-024-00540-3

Hoosemans L, Vooijs M, Hoeben A. Opportunities and challenges of small molecule inhibitors in glioblastoma treatment: Lessons learned from clinical trials. Cancers 16, 3021, 2024. DOI: 10.3390/cancers16173021

Giuranno L et al. Enhanced radiation sensitivity, decreased DNA damage repair, and differentiation defects in airway stem cells derived from patients with chronic obstructive pulmonary disease. Stem Cells Transl Med 13, 927-939, 2024. DOI: 10.1093/stcltm/szae043

Hounjet J et al. The DMT1 isoform lacking the iron-response element regulates normal and malignant hematopoiesis via NOTCH pathway activation. FEBS Lett 598, 1506-1512, 2024. DOI: 10.1002/1873-3468.14870