August 23^rd at 11:00
On-site event
3^rd floor Biochemistry seminar room, BioCity A-staircase

Coffee and pulla for the first 35 people

Professor Jim Norman, CRUK Beatson Institute, Glasgow, UK
Exploiting the circulating metabolome to discover critical events in cancer invasion and metastasis
Host: Johanna Ivaska (Johanna.ivaska@utu.fi)

It is now clear that the microenvironment is key to determining the likelihood and rate at which mutated cells form malignant tumours, or remain quiescent. The Norman lab focuses on communication between cancer cells and different microenvironments on the path to metastasis.  Key words: cancer, invasion, metastasis, metabolism, protein synthesis, ribosomes, exosomes, endosome trafficking, integrins, extracellular matrix

Selected publications 

Wilson B, Flett C, Gemperle J, Lawless C, Hartshorn M, Hinde E, Harrison T, Chastney M, Taylor S, Allen J, Norman JC, Zacharchenko T, Caswell PT. Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families. J Cell Sci. 2023 Jun 15;136(12):jcs260468. doi: 10.1242/jcs.260468. Epub 2023 Jun 23. PMID: 37232246; PMCID: PMC10323252.

Marco S, Neilson M, Moore M, Perez-Garcia A, Hall H, Mitchell L, Lilla S, Blanco GR, Hedley A, Zanivan S, Norman JC. Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion. Nat Commun. 2021 Nov 24;12(1):6829. doi: 10.1038/s41467-021-26839-y. PMID: 34819513; PMCID: PMC8613289.

Rabas N, Palmer S, Mitchell L, Ismail S, Gohlke A, Riley JS, Tait SWG, Gammage P, Soares LL, Macpherson IR, Norman JC. PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness. J Cell Biol. 2021 Dec 6;220(12):e202006049. doi: 10.1083/jcb.202006049. Epub 2021 Oct 8. PMID: 34623384; PMCID: PMC8641410.

Koessinger AL, Koessinger D, Stevenson K, Cloix C, Mitchell L, Nixon C, Gomez-Roman N, Chalmers AJ, Norman JC, Tait SWG. Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts. Sci Rep. 2020 Sep 21;10(1):15361. doi: 10.1038/s41598-020-72322-x. PMID: 32958777; PMCID: PMC7506024.

Novo D, Heath N, Mitchell L, Caligiuri G, MacFarlane A, Reijmer D, Charlton L, Knight J, Calka M, McGhee E, Dornier E, Sumpton D, Mason S, Echard A, Klinkert K, Secklehner J, Kruiswijk F, Vousden K, Macpherson IR, Blyth K, Bailey P, Yin H, Carlin LM, Morton J, Zanivan S, Norman JC. Mutant p53s generate pro- invasive niches by influencing exosome podocalyxin levels. Nat Commun. 2018 Nov 29;9(1):5069. doi: 10.1038/s41467-018-07339-y. PMID: 30498210; PMCID: PMC6265295.