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UID:94@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20230823T110000
DTEND;TZID=Europe/Helsinki:20230823T120000
DTSTAMP:20231013T055334Z
URL:https://biocityturku.fi/events/cellcom-seminar-norman/
SUMMARY:CellCom Seminar: Norman
DESCRIPTION:August 23rd at 11:00\nOn-site event\n3rd floor Biochemistry sem
 inar room\, BioCity A-staircase\n\nCoffee and pulla for the first 35 peopl
 e\n\n&nbsp\;\n\nProfessor Jim Norman\, CRUK Beatson Institute\, Glasgow\, 
 UK\nExploiting the circulating metabolome to discover critical events in c
 ancer invasion and metastasis\nHost: Johanna Ivaska (Johanna.ivaska@utu.fi
 )\n\nIt is now clear that the microenvironment is key to determining the l
 ikelihood and rate at which mutated cells form malignant tumours\, or rema
 in quiescent. The Norman lab focuses on communication between cancer cells
  and different microenvironments on the path to metastasis.  Key words: c
 ancer\, invasion\, metastasis\, metabolism\, protein synthesis\, ribosomes
 \, exosomes\, endosome trafficking\, integrins\, extracellular matrix\n\n&
 nbsp\;\n\nSelected publications  \n\nWilson B\, Flett C\, Gemperle J\, La
 wless C\, Hartshorn M\, Hinde E\, Harrison T\, Chastney M\, Taylor S\, All
 en J\, Norman JC\, Zacharchenko T\, Caswell PT. Proximity labelling identi
 fies pro-migratory endocytic recycling cargo and machinery of the Rab4 and
  Rab11 families. J Cell Sci. 2023 Jun 15\;136(12):jcs260468. doi: 10.1242/
 jcs.260468. Epub 2023 Jun 23. PMID: 37232246\; PMCID: PMC10323252.\n\nMarc
 o S\, Neilson M\, Moore M\, Perez-Garcia A\, Hall H\, Mitchell L\, Lilla S
 \, Blanco GR\, Hedley A\, Zanivan S\, Norman JC. Nuclear-capture of endoso
 mes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cel
 l invasion. Nat Commun. 2021 Nov 24\;12(1):6829. doi: 10.1038/s41467-021-2
 6839-y. PMID: 34819513\; PMCID: PMC8613289.\n\nRabas N\, Palmer S\, Mitche
 ll L\, Ismail S\, Gohlke A\, Riley JS\, Tait SWG\, Gammage P\, Soares LL\,
  Macpherson IR\, Norman JC. PINK1 drives production of mtDNA-containing ex
 tracellular vesicles to promote invasiveness. J Cell Biol. 2021 Dec 6\;220
 (12):e202006049. doi: 10.1083/jcb.202006049. Epub 2021 Oct 8. PMID: 346233
 84\; PMCID: PMC8641410.\n\nKoessinger AL\, Koessinger D\, Stevenson K\, Cl
 oix C\, Mitchell L\, Nixon C\, Gomez-Roman N\, Chalmers AJ\, Norman JC\, T
 ait SWG. Quantitative in vivo bioluminescence imaging of orthotopic patien
 t-derived glioblastoma xenografts. Sci Rep. 2020 Sep 21\;10(1):15361. doi:
  10.1038/s41598-020-72322-x. PMID: 32958777\; PMCID: PMC7506024.\n\nNovo D
 \, Heath N\, Mitchell L\, Caligiuri G\, MacFarlane A\, Reijmer D\, Charlto
 n L\, Knight J\, Calka M\, McGhee E\, Dornier E\, Sumpton D\, Mason S\, Ec
 hard A\, Klinkert K\, Secklehner J\, Kruiswijk F\, Vousden K\, Macpherson 
 IR\, Blyth K\, Bailey P\, Yin H\, Carlin LM\, Morton J\, Zanivan S\, Norma
 n JC. Mutant p53s generate pro- invasive niches by influencing exosome pod
 ocalyxin levels. Nat Commun. 2018 Nov 29\;9(1):5069. doi: 10.1038/s41467-0
 18-07339-y. PMID: 30498210\; PMCID: PMC6265295.
CATEGORIES:BiocityTurku events,Other events
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