Claire Edwards The role of the bone microenvironment in cancer-induced bone disease

Host: Johanna Tuomela ( jomitu@utu.fi )

Coffee sponsored by Aurexel Life Sciences at 9.45 am

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Claire Edwards obtained a first class honours degree and Ph.D. from the University of Sheffield, where she began her career in bone oncology. She undertook postdoctoral studies at the University of Sheffield and the University of Oxford.

Claire then relocated to the University of Texas Health Science Center at San Antonio, and subsequently Vanderbilt University to work with the late Prof. Gregory Mundy as an Assistant Professor. In 2010, she was recruited to the University of Oxford, where she is currently an Associate Professor with a joint appointment between the Nuffield Dept. of Surgical Sciences (NDS) and the Nuffield Dept. of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS). She is also a Fellow of St. Edmund Hall. Dr. Edwards is the recipient of multiple awards and fellowships, including the Iain T. Boyle Award from the European Calcified Tissue Society.

Prof. Edwards runs the Bone Oncology Group at the Botnar Research Centre, University of Oxford. Specific interests include the contributions of the host bone marrow microenvironment and the role of obesity, adipocytes and adipokines to the pathogenesis of MGUS, multiple myeloma and prostate cancer bone metastases.

https://www.medsci.ox.ac.uk/study/graduateschool/supervisors/claire-edwards

Selected publications:

1. Rao, S.R., Snaith, A., Marino, D., Cheng, X., Lwin, S.T., Orriss, I., Hamdy, F.C., Edwards, C.M. Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer. (2017). British Journal of Cancer 116(2); 227-236.
2. Lwin, S.T., Fowler, J.A., Drake, M.T., Edwards, J.R., Lynch, C.C., Edwards, C.M. A loss of host-derived MMP-7 promotes myeloma growth and osteolytic bone disease (2017). Molecular Cancer 16(1):49
3. Lwin, S.T., Olechnowicz, S.W.Z., Fowler, J.A., Edwards, C.M. Diet-induced obesity promotes a myeloma-like condition in vivo. (2015) Leukemia 29(2); 507-10.
4. Fowler J.A., Mundy G.R., Lwin S.T., Edwards C.M. Bone marrow stromal cells create a permissive microenvironment for myeloma development: a new stromal role for Wnt inhibitor Dkk1. (2012) Cancer Research, 72(9): 2183-9.
5. Fowler, J.A., Lwin, S.T., Drake, M.T., Edwards, J.R., Kyle, R.A., Mundy, G.R., Edwards, C.M. Host-derived adiponectin is tumor-suppressive and a novel therapeutic target for multiple myeloma and the associated bone disease. (2011) Blood 118; 5872-82.