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UID:322@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20181009T100000
DTEND;TZID=Europe/Helsinki:20181009T110000
DTSTAMP:20231013T061927Z
URL:https://biocityturku.fi/events/lifespan-seminar-the-role-of-the-bone-m
 icroenvironment-in-cancer-induced-bone-disease/
SUMMARY:Lifespan seminar: The role of the bone microenvironment in cancer-i
 nduced bone disease
DESCRIPTION:Claire Edwards The role of the bone microenvironment in cancer-
 induced bone disease\n\nHost: Johanna Tuomela ( jomitu@utu.fi )\n\nCoffee 
 sponsored by Aurexel Life Sciences at 9.45 am\n\n-------------------------
 -----------------------------------------------------------------------\n\
 nClaire Edwards obtained a first class honours degree and Ph.D. from the U
 niversity of Sheffield\, where she began her career in bone oncology. She 
 undertook postdoctoral studies at the University of Sheffield and the Univ
 ersity of Oxford.\n\nClaire then relocated to the University of Texas Heal
 th Science Center at San Antonio\, and subsequently Vanderbilt University 
 to work with the late Prof. Gregory Mundy as an Assistant Professor. In 20
 10\, she was recruited to the University of Oxford\, where she is currentl
 y an Associate Professor with a joint appointment between the Nuffield Dep
 t. of Surgical Sciences (NDS) and the Nuffield Dept. of Orthopaedics\, Rhe
 umatology and Musculoskeletal Sciences (NDORMS). She is also a Fellow of S
 t. Edmund Hall. Dr. Edwards is the recipient of multiple awards and fellow
 ships\, including the Iain T. Boyle Award from the European Calcified Tiss
 ue Society.\n\nProf. Edwards runs the Bone Oncology Group at the Botnar Re
 search Centre\, University of Oxford. Specific interests include the contr
 ibutions of the host bone marrow microenvironment and the role of obesity\
 , adipocytes and adipokines to the pathogenesis of MGUS\, multiple myeloma
  and prostate cancer bone metastases.\n\nhttps://www.medsci.ox.ac.uk/study
 /graduateschool/supervisors/claire-edwards\n\nSelected publications:\n\n 	
 Rao\, S.R.\, Snaith\, A.\, Marino\, D.\, Cheng\, X.\, Lwin\, S.T.\, Orriss
 \, I.\, Hamdy\, F.C.\, Edwards\, C.M. Tumour-derived alkaline phosphatase 
 regulates tumour growth\, epithelial plasticity and disease-free survival 
 in metastatic prostate cancer. (2017). British Journal of Cancer 116(2)\; 
 227-236.\n 	Lwin\, S.T.\, Fowler\, J.A.\, Drake\, M.T.\, Edwards\, J.R.\, 
 Lynch\, C.C.\, Edwards\, C.M. A loss of host-derived MMP-7 promotes myelom
 a growth and osteolytic bone disease (2017). Molecular Cancer 16(1):49\n 	
 Lwin\, S.T.\, Olechnowicz\, S.W.Z.\, Fowler\, J.A.\, Edwards\, C.M. Diet-i
 nduced obesity promotes a myeloma-like condition in vivo. (2015) Leukemia 
 29(2)\; 507-10.\n 	Fowler J.A.\, Mundy G.R.\, Lwin S.T.\, Edwards C.M. Bon
 e marrow stromal cells create a permissive microenvironment for myeloma de
 velopment: a new stromal role for Wnt inhibitor Dkk1. (2012) Cancer Resear
 ch\, 72(9): 2183-9.\n 	Fowler\, J.A.\, Lwin\, S.T.\, Drake\, M.T.\, Edward
 s\, J.R.\, Kyle\, R.A.\, Mundy\, G.R.\, Edwards\, C.M. Host-derived adipon
 ectin is tumor-suppressive and a novel therapeutic target for multiple mye
 loma and the associated bone disease. (2011) Blood 118\; 5872-82.\n
CATEGORIES:BiocityTurku events
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DTSTART:20180325T040000
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