5th November at 14:00
Online event
in Zoom

Prof. Niels Ødum, LEO Foundation Skin Immunology Research Center, University of Copenhagen
How bacteria may fuel cutaneous T cell lymphoma

Host: Riitta Lahesmaa (rilahes@utu.fi)

Link to the online seminar: https://utu.zoom.us/j/68943593707

Immunology seminar series is jointly organised by the Finnish Society for Immunology, InFLAMES Flagship and Turku Bioscience. For further information contact Anne Lahdenperä ( ankahy@utu.fi ) or Riitta Lahesmaa ( rilahes@utu.fi ), University of Turku.

Niels Ødum is full professor in immunology at the Health Science Faculty, University of Copenhagen since 2012. He did his PhD in the University of Copenhagen and after visiting research fellow periods in Fred Hutchinson Cancer Research, Seattle, USA and Kyushu University in Fukuoka, Japan, he became associate professor and after that full professor at the department of Biology in the University of Copenhagen. He was appointed as the Executive Director at the LEO Foundation Skin Immunology Research Center in University of Copenhagen this year.

Niels Ødum together with his research group has made scientific discoveries including identifying new HLA genes, their function and importance in transplantation and autoimmunity. He has made discoveries unravelling Interleukin-2 signal cascades and pathological signalling in T cell lymphoma and made discoveries of oncogenes and their targets and functions. He has also carried out research in diagnostic miRNA profiling of inflammatory skin disorders, identification of novel therapeutic targets and the role of bacteria in driving T cell lymphoma and drug resistance.

Niels Ødum is author of 350 papers in peer-reviewed journals and patents/patent applications within the fields of immunology, immune pathology, signal transduction and gene regulation with more than 12.800 citations and H-index 62. He is also reviewer for multiple international journals and organizer/co-organizer of several international conferences.

Selected publications

Vadivel CK, Willerslev-Olsen A, Namini MRJ, Zeng Z, Yan L, Danielsen M, Gluud M, Pallesen EMH, Wojewoda K, Osmancevic A, Hedebo S, Chang YT, Lindahl LM, Koralov SB, Geskin LJ, Bates SE, Iversen L, Litman T, Bech R, Wobser M, Guenova E, Kamstrup MR, Ødum N, Buus TB. Staphylococcus aureus induces drug resistance in cancer T cells in Sézary syndrome. Blood. 2024 Apr 11;143(15):1496-1512. doi: 10.1182/blood.2023021671. PMID: 38170178; PMCID: PMC11033614.

Zeng Z, Vadivel CK, Gluud M, Namini MRJ, Yan L, Ahmad S, Hansen MB, Coquet J, Mustelin T, Koralov SB, Bonefeld CM, Woetmann A, Geisler C, Guenova E, Kamstrup MR, Litman T, Gjerdrum LR, Buus TB, Ødum N. Keratinocytes Present Staphylococcus aureus Enterotoxins and Promote Malignant and Nonmalignant T Cell Proliferation in Cutaneous T-Cell Lymphoma. J Invest Dermatol. 2024 May 16:S0022-202X(24)00377-4. doi: 10.1016/j.jid.2024.04.018. Epub ahead of print. PMID: 38762064.

Pallesen EMH, Gluud M, Vadivel CK, Buus TB, de Rooij B, Zeng Z, Ahmad S, Willerslev-Olsen A, Röhrig C, Kamstrup MR, Bay L, Lindahl L, Krejsgaard T, Geisler C, Bonefeld CM, Iversen L, Woetmann A, Koralov SB, Bjarnsholt T, Frieling J, Schmelcher M, Ødum N. Endolysin Inhibits Skin Colonization by Patient-Derived Staphylococcus Aureus and Malignant T-Cell Activation in Cutaneous T-Cell Lymphoma. J Invest Dermatol. 2023 Sep;143(9):1757-1768.e3. doi: 10.1016/j.jid.2023.01.039. Epub 2023 Mar 7. PMID: 36889662.