Frontiers of Science: Immune landscape of hematological malignancies and immunomonitoring at a single cell level

Event Details

Frontiers of Science: Immune landscape of hematological malignancies and immunomonitoring at a single cell level

Prof. Satu Mustjoki, University of Helsinki, Finland

host: Riitta Lahesmaa (riitta.lahesmaa@utu.fi)

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Dr. Satu Mustjoki, MD, PhD is a professor of Translational Hematology at the University of Helsinki, Finland and a specialist in Clinical Chemistry (laboratory hematology). She has led several translational immunological biomarker studies in conjunction with the international clinical trials in leukemia. Her current research focuses on tumor immunology and on the molecular mechanisms of T-cell malignancies and associated autoimmune disorders and is supported by ERC among several other national and international awards (www.helsinki.fi/hematology). She leads the Translational Immunology Research Program at the Faculty of Medicine, University of Helsinki, Finland (www.helsinki.fi/trimm). She has > 140 publications including those published in New England Journal of Medicine, Nature Genetics, Nature Communications, Blood, and Cancer Cell.

Selected publications

Dufva O*, Polonen P*, Bruck O, Keranen MAI, Klievink J, Mehtonen J, Huuhtanen J, Kumar A, Malani D, Siitonen S, Kankainen M, Ghimire B, Lahtela J, Mattila P, Vaha-Koskela M, Wennerberg K, Granberg K, Leivonen SK, Meriranta L, Heckman C, Leppa S, Nykter M, Lohi O, Heinaniemi M*, Mustjoki S*.  Immunogenomic Landscape of Hematological Malignancies. Cancer Cell. 2020. doi: 10.1016/j.ccell.2020.06.002. *shared

Kim D, Park G, Huuhtanen J, Lundgren S, Khajuria RK, Hurtado AM, Munoz-Calleja C, Cardenoso L, Gomez-Garcia de Soria V, Chen-Liang TH, Eldfors S, Ellonen P, Hannula S, Kankainen M, Bruck O, Kreutzman A, Salmenniemi U, Lonnberg T, Jerez A, Itala-Remes M, Myllymaki M, Keranen MAI, Mustjoki S. Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease. Nat Commun. 2020;11(1):2246.

Dufva O, Koski J, Maliniemi P, Ianevski A, Klievink J, Leitner J, Polonen P, Hohtari H, Saeed K, Hannunen T, Ellonen P, Steinberger P, Kankainen M, Aittokallio T, Keranen MAI, Korhonen M, Mustjoki S. Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity. Blood. 2020;135(9):597-609.

Dufva O, Kankainen M, Kelkka T, Sekiguchi N, Awad SA, Eldfors S, Yadav B, Kuusanmaki H, Malani D, Andersson EI, Pietarinen P, Saikko L, Kovanen PE, Ojala T, Lee DA, Loughran TP, Jr., Nakazawa H, Suzumiya J, Suzuki R, Ko YH, Kim WS, Chuang SS, Aittokallio T, Chan WC, Ohshima K, Ishida F, Mustjoki S. Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target. Nat Commun. 2018;9(1):1567.

Savola P, Kelkka T, Rajala HL, Kuuliala A, Kuuliala K, Eldfors S, Ellonen P, Lagstrom S, Lepisto M, Hannunen T, Andersson EI, Khajuria RK, Jaatinen T, Koivuniemi R, Repo H, Saarela J, Porkka K, Leirisalo-Repo M, Mustjoki S. Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis. Nat Commun. 2017;8:15869.

Start: Thursday, November 26, 2020 at 12:00

End: Thursday, November 26, 2020 at 13:00


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