25^th September at 16:00
Onsite event
in Auditorium Biologi, BioCity 2^nd floor

Assoc. Prof. Emma Andersson, Karolinska Institute, Sweden
Title TBA

Host: Cecilia Sahlgren (cecilia.sahlgren@abo.fi)

Coffee, tea and buns served at 15:45

Join us for an inspiring seminar by Assoc. Prof. Emma Andersson. Dr. Andersson is a group leader at the Department of Cell and Molecular Biology, Karolinska Institute, Sweden. Her research focuses on the molecular mechanisms that guide the acquisition of cell identity and organ architecture, as well as how genetic mutations lead to developmental defects. Her lab has developed several novel molecular and biological tools to study RNA interference, genetic disease (i.e., Alagille Syndrome), and organ system-specific lineage segregation. The Andersson Lab has made seminal discoveries relating to the molecular mechanisms by which missense mutations in the Notch ligand Jagged1 lead to morphological and functional defects in the liver, vasculature, and the organ of Corti. Most recently, they have uncovered how ectodermal tissues compartmentalize during development by combining genetic manipulation of ectodermal progenitors in single-cell resolution with next-generation sequencing.

Selected publications

de Haan et al., 2025, “Ectoderm barcoding reveals neural and cochlear compartmentalization” Science

Kosek et al., 2025, Mapping effective microRNA pairing beyond the seed using abasic modifications” Nucleic Acids Research

Masek et al., 2024, “Jag1 Insufficiency Alters Liver Fibrosis via T Cell and Hepatocyte Differentiation Defects”, EMBO Molecular Medicine

de Haan et al., 2024, “Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial compartment of the developing cochlea” Development

Hankeova et al., 2022, “Sex differences and risk factors for bleeding in Alagille syndrome”, EMBO Molecular Medicine

Mangold et al., 2022, “Murine neural plate targeting by in utero nano-injection (NEPTUNE)”, JoVE

Andersson et al., 2018, “Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations” Gastroenterology