Frontiers of Science: Connecting cell metabolism with DNA Damage Response


February 6, 2020    
12:00 pm - 1:00 pm


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Prof. Marco Foiani, IFOM, The FIRC Institute of Molecular Oncology, Milan Italy & University of Milan, Italy
Connecting cell metabolism with DNA Damage Response

Host: Jukka Westermarck (

Marco Foiani is Professor of Molecular Biology at the University of Milan and, since 2009, Scientific Director of IFOM, an international cancer center that hosts 20 groups and 300 scientists. Prof. Foiani has studied different cellular processes (translational, chromosome replication, DNA recombination, DNA repair, DNA topology, transcription, autophagy and nuclear envelope dynamics) and regulatory pathways (translational control, cell cycle, checkpoint, sumo and ubiquitin pathways, protein acetylation, gene gating) using a variety of approaches (biochemical, genetic, imaging, genomic, molecular biology). His major contributions are within the fields of chromosome dynamics and genome integrity. His work has contributed to elucidate the ATR and ATM-dependent checkpoint processes controlling the interfaces between DNA replication, recombination, transcription and DNA topology and preventing abnormal chromosome transitions.



A model of DNA damage response activation at stalled replication forks by SPRTN.
Bruhn C, Foiani M. Nat Commun. 2019 Dec 12;10(1):5671

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis.
Elgendy M, Cirò M, Hosseini A, Weiszmann J, Mazzarella L, Ferrari E, Cazzoli R, Curigliano G, DeCensi A, Bonanni B, Budillon A, Pelicci PG, Janssens V, Ogris M, Baccarini M, Lanfrancone L, Weckwerth W, Foiani M, Minucci S. Cancer Cell. 2019 May 13;35(5):798-815.e5

An Error-Prone Polymerase in the Fight against Cancer.
Achar YJ, Foiani M. Cell. 2019 Mar 7;176(6):1241-1243

A Mad2-Mediated Translational Regulatory Mechanism Promoting S-Phase Cyclin Synthesis Controls Origin Firing and Survival to Replication Stress.
Gay S, Piccini D, Bruhn C, Ricciardi S, Soffientini P, Carotenuto W, Biffo S, Foiani M. Mol Cell. 2018 May 17;70(4):628-638.e5

PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response.
Ferrari E, Bruhn C, Peretti M, Cassani C, Carotenuto WV, Elgendy M, Shubassi G, Lucca C, Bermejo R, Varasi M, Minucci S, Longhese MP, Foiani M. Mol Cell. 2017 Jul 20;67(2):266-281.e4