September 13^th at 15:00
Online event
Flyer

Sampsa Hautaniemi, DTech, Professor of Systems Biology, Faculty of Medicine, University of Helsinki
Characterizing and overcoming chemotherapy resistance mechanisms in ovarian cancer

The seminar will be held online (Microsoft Teams) and is open to everyone interested in cancer research.

Get to know the Speaker:
https://www.helsinki.fi/en/researchgroups/systems-biology-of-drug-resistance-in-cancer
Research Program in Systems Oncology (ONCOSYS) & EU Horizon 2020 consortium DECIDER

Abstract

Chemotherapy resistance is one of the greatest contributors to cancer mortality. A prime example of the impact of our current inability to overcome treatment resistance is seen in ovarian high grade serous carcinoma (HGSC), which is the most common subtype of epithelial ovarian cancer. While 90% of HGSC patients show no clinically detectable signs of cancer after surgery and chemotherapy, tumors become progressively resistant to chemotherapy leading to five-year survival of <40%.

We have established a prospective, longitudinal, multiregion observational study DECIDER (ClinicalTrials.gov identifier NCT04846933) to characterize and overcome chemotherapy resistance in HGSC. In this presentation, I will discuss our latest findings on chemotherapy resistance mechanisms in HGSC, derived from comprehensive patient-level data and ex vivo experiments. Specifically, I will focus on highlighting computational methods that facilitate high-quality data collection from patient samples, HGSC tumor evolution before and during chemotherapy, as well as translating research findings to benefit patients.

Organizer: FICAN South, Eteläinen syöpäkeskus

Welcome!