Prof. Johannes Eble, University of Münster, Germany
Neuropilin-1 is a novel target for snake venoms with distinct functions on different types of vasculature.

Host: Jyrki Heino (jyrki.heino@utu.fi)

Coffee/tea served at 14:00

Dr. Johannes Eble is Professor of Biochemistry and the Head of the Institute of Physiological Chemistry and Pathobiochemistry at the University of Münster, Germany. His research is focused on collagen- and laminin-binding integrins, especially in the vasculature system. The integrin-mediated interaction of cells with extracellular matrix is of great importance for vasculature development and is often altered in pathological conditions such as inflammation and tumor formation. Professor Eble’s laboratory also studies how naturally occurring integrin inhibitors could be translated into medical practices. Professor Eble has published nearly 150 research articles.

Selected recent publications
Oliveira, L.S.; Estevão-Costa, M.I.; Alvarenga, V.G.; Vivas-Ruiz, D.E.; Yarleque, A.; Lima, A.M.; Cavaco, A.; Eble, J.A.; Sanchez, E.F. Atroxlysin-III, A Metalloproteinase from the Venom of the Peruvian Pit Viper Snake Bothrops atrox (Jergón) Induces Glycoprotein VI Shedding and Impairs Platelet Function. Molecules 2019, 24, 3489.

Lima, A.M., Cavaco, A.M., Fraga-Silva, R.A., Eble, J.A., Stergiopulos, N. From Patients to Platelets and Back Again: Pharmacological Approaches to Glycoprotein VI, a Thrilling Antithrombotic Target with Minor Bleeding Risks. Thromb Haemost. 2019. doi: 10.1055/s-0039-1695770.

Niland S, Eble JA. Neuropilins in the Context of Tumor Vasculature. Int J Mol Sci. 2019;20(3):639. doi:10.3390/ijms20030639

Rezaei, M., Cavaco, A.M., Seebach, J., Niland, S., Zimmermann, J., Hanschmann, EM., Hallmann, R., Hermann Schillers H. and Eble, JA. Signals of the Neuropilin-1–MET Axis and Cues of Mechanical Force Exertion Converge to Elicit Inflammatory Activation in Coherent Endothelial Cells. J Immunol 2019, 202 (5) 1559-1572; DOI: https://doi.org/10.4049/jimmunol.1801346