Event Details

21^st May at 14:45-16:00
Onsite event
in Säätiö lecture hall, Medisiina D

Cory Abate-Shen, Ph.D., Columbia University
How circulating tumor cells find their way to distant sites — studying metastasis in genetically engineered mouse models

Host: Maria Sundvall (mahesu@utu.fi)

Dr. Abate-Shen is an internationally recognized leader in genitourinary malignancies. Her innovative studies of genetically engineered mouse models for these cancers have led to the discovery of new biomarkers for early detection, as well as advances in cancer prevention and treatment. Her studies of castration-resistant prostate cancer led to the identification of lineage plasticity as a key mechanism of drug resistance, and her investigations of prostate cancer metastasis have elucidated new mechanisms of metastasis as well as potential new targets for treating bone metastasis.

Get to know the speaker:
Abate-Shen Lab | Department of Molecular Pharmacology and Therapeutics
https://systemsbiology.columbia.edu/news/cory-abate-shen-elected-to-national-academy-of-sciences

Selected publications

Arriaga JM, Ronaldson-Bouchard K, Picech F, Nunes de Almeida F, Afari S, Chhouri H, Vunjak-Novakovic G, Abate-Shen C. In vivo genome-wide CRISPR screening identifies CITED2 as a driver of prostate cancer bone metastasis. Oncogene. 2024 Apr;43(17):1303-1315.

Vasciaveo A, Arriaga JM, de Almeida FN, …, Rubin MA, Shen MM, Califano A, Abate-Shen C. OncoLoop: A Network-Based Precision Cancer Medicine Framework. Cancer Discov. 2023 Feb 6;13(2):386-409.

Papachristodoulou A, Rodriguez-Calero A, …, Mitrofanova A, Dutta A, Abate-Shen C. NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation. Cancer Discov. 2021 Sep;11(9):2316-2333.

Arriaga JM, Panja S, Alshalalfa M, …, Rabadan R, Sims PA, Mitrofanova A, Abate-Shen C. A MYC and RAS co-activation signature in localized prostate cancer drives bone metastasis and castration resistance. Nat Cancer. 2020 Nov;1(11):1082-1096.