Frontiers of Science

April 3^rd at 12:00
Onsite event
in Presidentti auditorium, BioCity
Spring 2025 program

Prof. Sampsa Hautaniemi, University of Helsinki
Characterizing and overcoming chemotherapy resistance in ovarian cancer
Host: Jukka Westermarck (jukwes@utu.fi)

Coffee and sandwich at 11:45, first come first served!

Six PhD researchers and early-career postdocs are welcome to have a lunch and discuss with Prof. Hautaniemi after the seminar. This is a great possibility to learn hosting skills in a friendly environment and create connections for future. Everyone is welcome to join, BioCity Turku will offer the lunch.

If you got interested, please send an email to biocityturku@bioscience.fi

Hautaniemi team conducts research to understand and overcome drug resistance in cancer. They use patient-derived multi-modal data, such as histopathology images, DNA/RNA/DNA methylation sequencing data, circulating tumor DNA, radiological images, clinical data and ex vivo data collected from observational, longitudinal and multi-region trial (DECIDER; ClinicalTrials ID: NCT04846933) to characterize chemotherapy resistance mechanisms in ovarian high grade serous carcinoma. The ultimate goal of their cross-disciplinary research is to translate these multi-modal data into testable predictions and further into benefits in cancer patient care.

Selected publications

Lahtinen A, Lavikka K, Virtanen A, Li Y, …,  Senkowski W, Kallunki T, Häkkinen A, Hynninen J, Oikkonen J, Hautaniemi S. Evolutionary states and trajectories characterized by distinct pathways stratify patients with ovarian high grade serous carcinoma. Cancer Cell. 2023 May 11:S1535-6108(23)00143-5.

Zhang K, Erkan EP, Jamalzadeh S, …, Häkkinen A, Hautaniemi S, Vähärautio A. Longitudinal single-cell RNA-seq analysis reveals stress-promoted chemoresistance in metastatic ovarian cancer. Science Advances. 2022 Feb 25;8(8).

Häkkinen A, Zhang K, Alkodsi A, …,  Hietanen S, Lehtonen R, Hautaniemi S. PRISM: recovering cell-type-specific expression profiles from individual composite RNA-seq samples. Bioinformatics. 2021 Sep 29;37(18):2882-2888.

Jamalzadeh S, Häkkinen A, Andersson N, Huhtinen K, Laury A, Hietanen S, Hynninen J, Oikkonen J, Carpén O, Virtanen A, Hautaniemi S. QuantISH: RNA in situ hybridization image analysis framework for quantifying cell type-specific target RNA expression and variability. Laboratory Investigation. 2022 Jul;102(7):753-761.

Oikkonen J, Zhang K, Salminen L, Schulman I, Lavikka K, Andersson N, Ojanperä E, Hietanen S, Grénman S, Lehtonen R, Huhtinen K, Carpén O, Hynninen J, Färkkilä A, Hautaniemi S. Prospective longitudinal ctDNA workflow reveals clinically actionable alterations in ovarian cancer. JCO Precision Oncology, 2019 :3, 1-12.

General information

• You can download and save all the spring 2025 FoS-seminars to your calendar from here: https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/
• Registration is not needed, participation list is circulated in the audience
• If you are a student and later wish to get a certificate of attendance from the Frontier of Science seminars, print out the seminar diary and after the seminar ask the BioCity coordinator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/
• Please note that any audio or video recording of the seminars is strictly forbidden.
• Spring 2025 image credits to Teemu Tuominen: Close up photograph of soil bacteria Streptomyces colonies border.