20^th December at 10:00
Onsite event
in Auditorium Biology (room 2097), BioCity 2^nd floor

Docent Kirsi Rilla, Institute of Biomedicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland.
Multiple Roles of Hyaluronan in Extracellular Vesicle Biology.

Dr. Kirsi Rilla is a senior researcher at the Institute of Biomedicine, School of Medicine, Faculty of Health Sciences at the University of Eastern Finland. Her research focuses on the biology of extracellular vesicles (EVs), with an emphasis on their surface properties and interactions.  Her team aims to uncover how EVs engage with the extracellular matrix and target cells, with special interest in hyaluronic acid and its primary receptor, CD44.

Selected publications

Matilainen J, Berg V, Vaittinen M, Impola U, Mustonen AM, Männistö V, Malinen M, Luukkonen V, Rosso N, Turunen T, Käkelä P, Palmisano S, Arasu UT, Sihvo SP, Aaltonen N, Härkönen K, Caddeo A, Kaminska D, Pajukanta P, Kaikkonen MU, Tiribelli C, Käkelä R, Laitinen S, Pihlajamäki J, Nieminen P, Rilla K. Increased secretion of adipocyte-derived extracellular vesicles is associated with adipose tissue inflammation and the mobilization of excess lipid in human obesity. J Transl Med (2024) Jul 4;22(1):623. doi: 10.1186/s12967-024-05249-w.

Aaltonen N, Kyykallio H, Tollis S, Capra J, Hartikainen JM, Matilainen J, Oikari S, Rilla K. MCF10CA Breast Cancer Cells Utilize Hyaluronan-Coated EV-Rich Trails for Coordinated Migration. Front Oncol (2022) Apr 27;12:869417. doi: 10.3389/fonc.2022.869417.

Capra J, Härkönen K, Kyykallio H, Vihinen H, Jokitalo E, Rilla K. Microscopic characterization reveals the diversity of EVs secreted by GFP-HAS3 expressing MCF7 cells. Eur J Cell Biol (2022) Jun-Aug;101(3):151235. doi: 10.1016/j.ejcb.2022.151235.

Rilla K. Diverse plasma membrane protrusions act as platforms for extracellular vesicle shedding. J Extracell Vesicles. 2021 Sep;10(11):e12148. doi: 10.1002/jev2.12148.