Frontiers of Science: The molecular chaperone Hsp90: probing its functions with drugs and gene deletion


April 8, 2021    
12:00 pm - 1:00 pm

Prof. Didier Picard, University of Geneva, Switzerland
online event at 12:00

host: Outi Salo-Ahen (

Register latest April 7th 12:00


Didier Picard is a professor and a research group leader in the department of cell biology in the University of Geneva, Switzerland. His research interests lies in signal integration at the cellular level and its implications in breast cancer, and particularly in understanding the molecular mechanisms of signal transduction by ER and its crosstalk with other intra- and extracellular signals. His group studies also the Hsp90 molecular chaperone machine where they are particularly interested in determining the in vivo functions of the Hsp90 molecular chaperone complex both in mammalian cells and in the mouse, using genetic, biochemical, proteomic and pharmacological tools.


Seleced publications

A Joshi, L Dai, Y Liu, J Lee, NM Ghahhari… D Picard (2020) The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis. BMC Biol. 18, 10

K Bhattacharya, L Weidenauer, TM Luengo… D Picard (2020) The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation. Nature Communications 11:5975

Segala G, Bennesch MA, Ghahhari NM, Pandey DP, Echeverria PC, Karch F, Maeda RK, Picard D (2019) Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling. Nature Communications 10:1833


General information

  • All spring 2021 Frontiers of Science seminars are arranged online as eTALKs.
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