Frontiers of Science: DNA sequence rearrangements in evolution and disease


October 4, 2018    
12:00 pm - 1:00 pm


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Prof. Martin Frith, National Institute of Advanced Industrial Science and Technology AIST, Tokyo, Japan

Host: Sofia Khan (

Graduate students and postdocs: If you would like to meet Professor Frith over a lunch after the seminar, please contact

Professor Martin Frith got his PhD from the Boston University in 2004. He did his postdoctoral training at the University of Queensland (Brisbane, Australia) and at the RIKEN (Tokyo, Japan) and further continued his research at the National Institute of Advanced Industrial Science and Technology (AIST) (Tokyo, Japan). He was appointed as a professor at the Department of Computational Biology and Medical Sciences in University of Tokyo. Dr Frith’s aim is to decipher the functional and historical information in genome sequences using statistical models and computational methods in close collaboration with experimental groups. Dr Frith has published multiple methods that are widely used in various fields from clinical and biomedical applications to microbial studies. His recent research has brought novel insights on rearrangements in human DNA.

Selected publications
Frith MC, Khan S. A survey of localized sequence rearrangements in human DNA. Nucleic Acids Res. 2018

Shrestha AMS, Frith MC, Asai K, Richard H. Jointly aligning a group of DNA reads improves accuracy of identifying large deletions. Nucleic Acids Res. 2018

Mitsuhashi S, Nakagawa S, Takahashi Ueda M, Imanishi T, Frith MC, Mitsuhashi H. Nanopore-based single molecule sequencing of the D4Z4 array responsible for facioscapulohumeral muscular dystrophy. Sci Rep. 2017

Frith MC, Kawaguchi R. Split-alignment of genomes finds orthologies more accurately. Genome Biol. 2015