December 12^th at 12:00
Onsite event
in Presidentti auditorium, BioCity

Prof. Torben Heick Jensen, Aarhus Universitet, Denmark
Nuclear sorting of RNA
Host: Matti Turtola (matti.turtola@utu.fi)

Coffee and sandwich at 11:45, first come first served!

Six PhD researchers and early-career postdocs are welcome to have a lunch and discuss with Prof. Jensen after the seminar. This is a great possibility to learn hosting skills in a friendly environment and create connections for future. Everyone is welcome to join, BioCity Turku will offer the lunch.

If you got interested, please send an email to biocityturku@bioscience.fi

Jensen laboratory studies the regulation and fidelity of gene expression which is of paramount importance for the maintenance and differentiation of all living organisms. The revelation that most of the human genome is transcriptionally active raises a new question how cells deal with all these transcripts, and the Jensen lab research is directed for understanding the fundamental transcriptome control mechanisms. These studies touch many areas of RNA metabolism like RNA decay, long non-coding RNAs, snoRNAs, RNA modifications, transposable elements, molecular recognition and RNA-binding proteins. Jensen laboratory also employs and develops methodologies to capture the transcriptome dynamics that goes technically far beyond the standard RNA-Seq analyses.

Selected publications

Rouvière JO, Salerno-Kochan A, Lykke-Andersen S, Garland W, Dou Y, Rathore O, Molska EŠ, Wu G, Schmid M, Bugai A, Jakobsen L, Žumer K, Cramer P, Andersen JS, Conti E, Jensen TH. (2023) ARS2 instructs early transcription termination-coupled RNA decay by recruiting ZC3H4 to nascent transcripts. Mol Cell. 83, 2240-2257.e6.

Garland W, Müller I, Wu M, Schmid M, Imamura K, Rib L, Sandelin A, Helin K, Jensen TH. (2022) Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression. Mol Cell. 82, 1691-1707.e8.

Lykke-Andersen S, Žumer K, Molska EŠ, Rouvière JO, Wu G, Demel C, Schwalb B, Schmid M, Cramer P, Jensen TH. (2021) Integrator is a genome-wide attenuator of non-productive transcription. Mol Cell. 81,514-529.e6.

Schmid M, Jensen TH. (2018) Controlling nuclear RNA levels. Nat Rev Genet. 19, 518-529.

General information

• You can download and save all the autumn 2024 FoS-seminars to your calendar from here: https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/
• Registration is not needed, participation list is circulated in the audience
• If you are a student and later wish to get a certificate of attendance from the Frontier of Science seminars, print out the seminar diary and after the seminar ask the BioCity coordinator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/
• Please note that any audio or video recording of the seminars is strictly forbidden.
• Autumn 2024 image credits to Mia Åstrand: Details of the Bacteroides fragilis VgrG protein (PDB ID: 8GRA). Image created in the PyMOL Molecular Graphics System, Version 2.5 Schrödinger, LLC.