September 22^nd at 12:00
on-site event
Presidentti auditorium, BioCity

Prof. Gwendalyn Randolph, Washington University School of Medicine St. Louis, USA
Let it go! (or not): regulation of the dissemination of cells and molecules from tissues during inflammation
host: Sirpa Jalkanen (sirpa.jalkanen@utu.fi)

Coffee and sandwich served at 11:45

Gwendalyn J. Randolph is the Emil R. Unanue Distinguished Professor in the Department of Immunology and Pathology at Washington University in St. Louis, Missouri, where she is currently co-director of the Immunology Graduate Program. During her postdoctoral work, Randolph characterized monocyte differentiation to dendritic cells and macrophages and made advances in our understanding of dendritic cell trafficking and the fate of monocytes recruited to sites of inflammation. Her lab has contributed to the Immunological Genome Project by characterizing macrophage gene expression. Her work now focuses on the immunological mechanisms driving atherosclerosis and inflammatory bowel disease (IBD) by exploring lymphatic function and lipoprotein trafficking.

Gwendalyn J. Randolph will be Sina Tadayon’s opponent 21.9.2022 and she will give a seminar 22.9.2022 at noon.

Selected publications

N Zhang, SH Kim, A Gainullina, …, BH Zinselmeyer, GJ Randolph, KW Kim. 2021. LYVE1hi macrophages reside in mesothelium and promote omentum-independent ovarian tumor growth in the peritoneum. J. Exp. Med., 218(12):e20210924. doi: 10.1084/jem.20210924.

Rafael S. Czepielewski, Emma C. Erlich, …, Gwendalyn J. Randolph. 2021. Ileitis-associated mesenteric tertiary lymphoid organs arise at lymphatic valves and impede lymph flow in response to tumor necrosis factor, Immunity, 54(12):2795-2811. doi: 10.1016/j.immuni.2021.10.003.

YH Han, EJ Onufer, RW Sprung, WS Davidson, .., GJ Randolph. 2021. Enterically derived high-density lipoprotein restrains liver injury through the portal vein. Science, 373, 410; doi: 10.1126/science.abe6729

LH Huang, P Deepak, MA Ciorba, B Mittendorfer, BW Patterson, GJ Randolph. 2020. Postprandial chylomicron output and transport through intestinal lymphatics are not impaired in active Crohn’s disease. Gastroenterology, 159:1955-9156. doi: 10.1053/j.gastro.2020.07.012

JW Williams, K Zaitsev, KW Kim S Ivanov, BT Saunders, …, GJ. Randolph. Limited proliferation capacity of aorta intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression. Nature Immunology, 21:1194-1204. doi: 10.1038/s41590-020-0768-4

PL Wang, AKY Yim, K Kim, D Avey, RS Czepielewski, M Colonna, J Milbrandt, GJ Randolph. 2020. Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia. Nature Communications, 11(1):2552. doi: 10.1038/s41467-020-16355-w