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UID:212@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20180507T120000
DTEND;TZID=Europe/Helsinki:20180507T130000
DTSTAMP:20231013T061228Z
URL:https://biocityturku.fi/events/special-seminar-types-and-initiators-of
 -mitochondrial-autophagy-mitophagy/
SUMMARY:Special seminar: Types and Initiators of Mitochondrial Autophagy (M
 itophagy)
DESCRIPTION:Prof. John Lemasters\nGlaxoSmithKline Distinguished Endowed Cha
 ir\nDirector\, Center for Cell Death\, Injury &amp\; Regeneration\nDepartm
 ents of Drug Discovery &amp\; Biomedical Sciences and Biochemistry &amp\; 
 Molecular Biology\nMedical University of South Carolina\, USA\n\nHost: Eev
 a-Liisa Eskelinen (eeva-liisa.eskelinen@utu.fi)\nIn case you wish to meet 
 with Prof. Lemasters\, please contact the host.\n\n&nbsp\;\n\nDr. Lemaster
 s’ research interests include the cellular and molecular mechanisms unde
 rlying toxic\, hypoxic and ischemia-reperfusion injury to liver and heart.
  His laboratory applies new techniques of laser scanning confocal and mult
 iphoton microscopy to characterize the physiology of single living cells\,
  including the assessment of ion homeostasis\, chelatable iron\, mitochond
 rial function\, electrical potentials\, oxygen and nitrogen free radical f
 ormation\, membrane permeability and other biochemical parameters during t
 he pathogenesis of lethal cell injury.\n\n Selected publications\n\nDeHar
 t DN\, Fang D\, Heslop K\, Li L\, Lemasters JJ\, Maldonado EN. Opening of 
 voltage dependent anion channels promotes reactive oxygen species generati
 on\, mitochondrial dysfunction and cell death in cancer cells. Biochem Pha
 rmacol. 2018 Feb\;148:155-162. doi: 10.1016/j.bcp.2017.12.022. Epub 2017 D
 ec 28.\n\nMaldonado EN\, DeHart DN\, Patnaik J\, Klatt SC\, Gooz MB\, Lema
 sters JJ. ATP/ADP turnover and import of glycolytic ATP into mitochondria 
 in cancer cells is independent of the adenine nucleotide translocator. J B
 iol Chem. 2017 Oct 13\;292(41):16969. doi: 10.1074/jbc.A116.734814.\n\nTep
 lova VV\, Kruglov AG\, Kovalyov LI\, Nikiforova AB\, Fedotcheva NI\, Lemas
 ters JJ. Glutamate contributes to alcohol hepatotoxicity by enhancing oxid
 ative stress in mitochondria. J Bioenerg Biomembr. 2017 Jun\;49(3):253-264
 . doi: 10.1007/s10863-017-9713-0. Epub 2017 May 6.\n\nLiu Q\, H Rehman\, Y
  Krishnasamy\, RG Schnellmann\, JJ Lemasters and Z Zhong. Improvement of l
 iver injury and survival by JNK2 and iNOS deficiency in liver transplants 
 from cardiac death mice. J Hepatol 2015\, 63:68-74.\n\n&nbsp\;
CATEGORIES:BiocityTurku events,Other events
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TZID:Europe/Helsinki
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DTSTART:20180325T040000
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