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UID:219@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20171215T120000
DTEND;TZID=Europe/Helsinki:20171215T130000
DTSTAMP:20231013T061301Z
URL:https://biocityturku.fi/events/special-seminar-exploring-the-role-of-r
 egulatory-rnas-in-skin-cancer/
SUMMARY:Special Seminar: Exploring the role of regulatory RNAs in skin canc
 er
DESCRIPTION:Associate Prof. Andor Pivarcsi\nCenter for Molecular Medicine\,
  Unit of Dermatology\, Karolinska Institutet\n\nHost: Veli-Matti Kähäri 
 (velkah@utu.fi)\n\nAndor Pivarcsi is associate professor in experimental d
 ermatology at the Center for Molecular Medicine in Karolinska Institutet. 
 His research group studies the role of non-coding RNAs (microRNAs and long
  non-coding RNAs) in the most common human malignancy\, skin cancer. Melan
 oma and non-melanoma skin cancers have an increasing incidence worldwide a
 nd there is a need for developing new therapeutic approaches and biomarker
 s. His research team investigates the involvement of non-coding RNAs in sk
 in carcinogenesis\, by identifying alterations in the activity of miRNA an
 d lncRNA genes in patient samples and by systematic investigation of their
  function using in vitro and in vivo disease models. The long-term goal is
  to translate the findings into the clinical practice and modulate miRNA e
 xpression in the skin via synthetic miRNAs or miRNA inhibitors in order to
  treat skin cancer.\n\n&nbsp\;\n\nSelected publications\n\nLohcharoenkal W
 \, Das Mahapatra K\, Pasquali L\, Crudden C\, Kular L\, Akkaya Ulum YZ\, Z
 hang L\, Xu Landén N\, Girnita L\, Jagodic M\, Ståhle M\, Sonkoly E\, Pi
 varcsi A. Genome-wide screen for microRNAs reveals a role for miR-203 in m
 elanoma metastasis. J Invest Dermatol. 2017 Nov 2. pii: S0022-202X(17)3313
 7-8.\n\nLi X\, Li D\, Wang A\, Chu T\, Lohcharoenkal W\, Zheng X\, Grünle
 r J\, Narayanan S\, Eliasson S\, Herter EK\, Wang Y\, Ma Y\, Ehrström M\,
  Eidsmo L\, Kasper M\, Pivarcsi A\, Sonkoly E\, Catrina SB\, Ståhle M\, X
 u Landén N. MicroRNA-132 with Therapeutic Potential in Chronic Wounds. J 
 Invest Dermatol. 2017 Dec\;137(12):2630-2638.\n\nLi X\, Li D\, Wikstrom JD
 \, Pivarcsi A\, Sonkoly E\, Ståhle M\, Landén NX. MicroRNA-132 promotes 
 fibroblast migration via regulating RAS p21 protein activator 1 in skin wo
 und healing. Sci Rep. 2017 Aug 10\;7(1):7797.\n\nSrivastava A\, Nikamo P\,
  Lohcharoenkal W\, Li D\, Meisgen F\, Xu Landén N\, Ståhle M\, Pivarcsi 
 A\, Sonkoly E. MicroRNA-146a suppresses IL-17-mediated skin inflammation a
 nd is genetically associated with psoriasis. J Allergy Clin Immunol. 2017 
 Feb\;139(2):550-561.\n\nLohcharoenkal W\,  Harada M\,  Lovén J\,  Meis
 gen F\,  Landén NX\,  Zhang L\,  Lapins J\,  Mahapatra KD\,  Shi H\,
   Nissinen L\,  Kähäri VM\,  Ståhle M\,  Sonkoly E\,  Grandér D\,
   Arsenian-Henriksson M\,  Pivarcsi A. MicroRNA-203 Inversely Correlates
  with Differentiation Grade\, Targets c-MYC\, and Functions as a Tumor Sup
 pressor in cSCC. The Journal of investigative dermatology 2016 136\;12 248
 5-2494\n\nLi D\, Wang A\, Liu X\, Meisgen F\, Grünler J\, Botusan IR\, Na
 rayanan S\, Erikci E\, Li X\, Blomqvist L\, Du L\, Pivarcsi A\, Sonkoly E\
 , Chowdhury K\, Catrina SB\, Ståhle M\, Landén NX. MicroRNA-132 enhances
  transition from inflammation to proliferation during wound healing. J Cli
 n Invest. 2015 Aug 3\;125(8):3008-26.
CATEGORIES:BiocityTurku events
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