BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN BEGIN:VEVENT UID:245@biocityturku.fi DTSTART;TZID=Europe/Helsinki:20180426T120000 DTEND;TZID=Europe/Helsinki:20180426T120000 DTSTAMP:20231013T061534Z URL:https://biocityturku.fi/events/special-seminar-associations-of-sorla-s orl1-with-alzheimers-disease/ SUMMARY:Receptor seminar: Associations of SORLA/SORL1 with Alzheimer’s di sease DESCRIPTION:Prof. Olav M Andersen\, Department of Biomedicine\, Aarhus Univ ersity\, Denmark\n\nIf you would like to meet with Prof Andersen\, please contact hellham@utu.fi\n\n \;\n\nAlzheimer’s disease (AD) is the mo st prevalent form of dementia\, but the underlying molecular mechanisms as well as the contribution of associated genetic risk factors are far from understood. I here describe accumulating evidence for SORL1 being an impor tant genetic AD risk factor encoding the neuronal sorting receptor SORLA t hat shows decreased expression in brain of AD patients.\n\nUsing cell and animal models\, we have found that SORLA activity protects against Amyloid β-peptide formation by determination of the intraneuronal sorting recept or of the Amyloid precursor protein due in the secretory and endocytic pat hways. We have identified cytoplasmic adaptor proteins that regulates SORL A sorting\, and found an endocytic/recycling pathway that modify N-glycosy lation priming the receptor for ectodomain shedding thus decreasing the in traneuronal bioavailability.\n\nMore recently\, we have uncovered cis-and trans regulatory mechanisms starting to explain the decrease of SORLA in A D\, as well as identified novel SORL1 transcripts that correlate with gene tic risk alleles and sheds light on novel receptor functions.\n\nIn conclu sion\, it was recently suggested that pathogenic mutations in the SORL1 ge ne should be considered next to the pathogenic mutations in PSEN1\, PSEN2 and APP\, and that SORL1 should be considered as “the fourth” autosoma l dominant Alzheimer gene.\n\nSelected publications\n\n\nMygind KJ\, Stör iko T\, Freiberg ML\, Samsøe-Petersen J\, Schwarz J\, Andersen OM\, Kveib org M (2018) Sorting nexin 9 (SNX9) regulates levels of the transmembrane disintegrin and metalloproteinase (ADAM)-9 at the cell surface. J Biol Che m. 2018 Apr 5. pii: jbc.RA117.001077. doi: 10.1074/jbc.RA117.001077. [Epub ahead of print]\n\nDienemann C\, Coburger I\, Mehmedbasic A\, Andersen OM \, Than ME (2015) Mutants of metal binding site M1 in APP E2 show metal sp ecific differences in binding of heparin but not of sorLA.  Biochemistry. 2015 Apr 21\;54(15):2490-9. doi: 10.1021/acs.biochem.5b00111. Epub 2015 A pr 10.\n\nMehmedbasic A\, Christensen SK\, Nilsson J\, Rüetschi U\, Gusta fsen C\, Poulsen AS\, Rasmussen RW\, Fjorback AN\, Larson G\, Andersen OM (2015) SorLA complement-type repeat domains protect the amyloid precursor protein against processing. J Biol Chem. 2015 Feb 6\;290(6):3359-76. doi: 10.1074/jbc.M114.619940. Epub 2014 Dec 18.\n\nWillnow TE\, Andersen OM (20 13) Sorting receptor SORLA--a trafficking path to avoid Alzheimer disease. J Cell Sci. 2013 Jul 1\;126(Pt 13):2751-60. doi: 10.1242/jcs.125393. Epub 2013 Jun 26. Review.\n\nFjorback AW\, Seaman M\, Gustafsen C\, Mehmedbasi c A\, Gokool S\, Wu C\, Militz D\, Schmidt V\, Madsen P\, Nyengaard JR\, W illnow TE\, Christensen EI\, Mobley WB\, Nykjær A\, Andersen OM (2012) Re tromer binds the FANSHY sorting motif in SorLA to regulate amyloid precurs or protein sorting and processing. J Neurosci. 2012 Jan 25\;32(4):1467-80. doi: 10.1523/JNEUROSCI.2272-11.2012.\n\nSerup Andersen O\, Boisguerin P\, Glerup S\, Skeldal S\, Volkmer R\, Willnow TE\, Nykjaer A\, Andersen OM ( 2010) Identification of a linear epitope in sortilin that partakes in pro- neurotrophin binding. J Biol Chem. 2010 Apr 16\;285(16):12210-22. doi: 10. 1074/jbc.M109.062364. Epub 2010 Feb 16.\n\nDodson SE\, Andersen OM\, Karma li V\, Fritz JJ\, Cheng D\, Peng J\, Levey AI\, Willnow TE\, Lah JJ (2008) Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidos is: evidence for a proximal role in Alzheimer's disease. J Neurosci. 2008 Nov 26\;28(48):12877-86. doi: 10.1523/JNEUROSCI.4582-08.2008 CATEGORIES:BiocityTurku events LOCATION:#_LOCATIONNAME\, #_LOCATIONFULLLINE\, #_LOCATIONCOUNTRY X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=#_LOCATIONFULLLINE\, #_LOCA TIONCOUNTRY;X-APPLE-RADIUS=100;X-TITLE=#_LOCATIONNAME:geo:0,0 END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20180325T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR