BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//wp-events-plugin.com//7.2.3.1//EN
BEGIN:VEVENT
UID:221@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20180215T150000
DTEND;TZID=Europe/Helsinki:20180215T160000
DTSTAMP:20231013T061302Z
URL:https://biocityturku.fi/events/smartbio-seminar-shaping-next-generatio
 n-aminoglycoside-antibiotics-for-treatment-of-multidrug-resistant-diseases
 /
SUMMARY:SmartBIO seminar: Shaping next generation aminoglycoside antibiotic
 s for treatment of multidrug-resistant diseases
DESCRIPTION:Prof. David Crich\, Wayne State University\, Detroit\, MI\, US\
 n\nHost: Reko Leino (reko.leino@abo.fi)\n\n&nbsp\;\n\nThe aminoglycoside a
 ntibiotics (AGAs) are listed by the WHO as one of the critically important
  classes of antimicrobials for human therapy. They continue to be of criti
 cal importance for the treatment of MRSA\, Gram-negative pathogens\, multi
 drug-resistant Mycobacterium tuberculosis\, and complex infectious disease
 s including exacerbated cystic fibrosis\, complicated urinary tract infect
 ions\, sepsis\, and chronic obstructive pulmonary disease. High efficacy\,
  antibacterial potency\, lack of drug-related allergy\, little interaction
  with other pharmacological substances and predominantly unchanged excreti
 on in the urine are well known attributes.\n\nHowever\, the clinical use o
 f AGAs and their development into more effective drugs unaffected by resis
 tance factors have been limited by their toxicity\, in particular reversib
 le kidney damage (nephrotoxicity) and especially irreversible hearing dama
 ge (ototoxicity). AGA ototoxicity affects as much as 20% of the patient po
 pulation\, with estimates as high as 37% in patients with mycobacterial di
 seases taking AGAs for long durations.\n\nThe lecture will cover the desig
 n\, synthesis and evaluation of next generation AGAs intended to retain hi
 gh antibacterial potency while minimizing ototoxicity. The ability of the 
 novel AGAs to circumvent common mechanisms of resistance will also be disc
 ussed.
CATEGORIES:BiocityTurku events
LOCATION:#_LOCATIONNAME\, #_LOCATIONFULLLINE\, #_LOCATIONCOUNTRY
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=#_LOCATIONFULLLINE\, #_LOCA
 TIONCOUNTRY;X-APPLE-RADIUS=100;X-TITLE=#_LOCATIONNAME:geo:0,0
END:VEVENT
BEGIN:VTIMEZONE
TZID:Europe/Helsinki
X-LIC-LOCATION:Europe/Helsinki
BEGIN:STANDARD
DTSTART:20171029T030000
TZOFFSETFROM:+0300
TZOFFSETTO:+0200
TZNAME:EET
END:STANDARD
END:VTIMEZONE
END:VCALENDAR