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UID:225@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20180525T090000
DTEND;TZID=Europe/Helsinki:20180525T100000
DTSTAMP:20231013T061303Z
URL:https://biocityturku.fi/events/smartbio-seminar-cyanobacterial-based-a
 pproaches-to-bioengineering-2/
SUMMARY:SmartBIO seminar: Cyanobacterial-based approaches to bioengineering
DESCRIPTION:Prof. Cheryl Kerfeld\, Lawrence Berkeley National Lab\, Michiga
 n State University\, US\n\nHost: Eva-Mari Aro\n\nBacterial microcompartmen
 ts are organelles that are involved in both autotrophic and heterotrophic 
 metabolism. They are similar to eukaryotic organelles in that they enclose
  proteins that work together within a selectively permeable membrane\, but
  it is a membrane composed entirely of protein\, not lipid. Cyanobacteria 
 use a microcompartment called the carboxysome to optimize carbon fixation.
  This is achieved by packing the enzymes RuBisCO (Ribulose Bisphosphate Ca
 rboxylase/Oxygenase) and carbonic anhydrase within the protein shell. The 
 shell also prevents the leakage of carbon dioxide\, the substrate for RuBi
 sCO. Through bioinformatic studies it is now evident that many other bacte
 ria use different types of microcompartments to efficiently degrade compou
 nds for energy production\, which involves sequestering toxic and volatile
  intermediates within the organelle. Kerfeld lab focuses its research on t
 hese bacterial microcompartments\, as well as in carbon fixation and cyano
 bacterial photoprotection mechanisms.\n\nSelected publications\n\nKerfeld 
 CA\, Aussignargues C\, Zarzycki J\, Cai F\, Sutter M. (2018) Bacterial mic
 rocompartments. Nat Rev Microbiol. 16(5):277-290\n\nBao H\, Melnicki MR\, 
 Pawlowski EG\, Sutter M\, Agostoni M\, Lechno-Yossef S\, Cai F\, Montgomer
 y BL\, Kerfeld CA. (2017) Additional families of orange carotenoid protein
 s in the photoprotective system of cyanobacteria. Nat Plants 10\;3:17089\n
 \nLechno-Yossef S\, Melnicki MR\, Bao H\, Montgomery BL\, Kerfeld CA. (201
 7) Synthetic OCP heterodimers are photoactive and recapitulate the fusion 
 of two primitive carotenoproteins in the evolution of cyanobacterial photo
 protection. Plant J. 91(4):646-656\n\nKirilovsky D\, Kerfeld CA. (2016) Cy
 anobacterial photoprotection by the orange carotenoid protein. Nat Plants.
  2\;2(12):16180. Review.
CATEGORIES:BiocityTurku events
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