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UID:856@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20260512T123000
DTEND;TZID=Europe/Helsinki:20260512T133000
DTSTAMP:20260409T083049Z
URL:https://biocityturku.fi/events/seminar-shimon-sakaguchi/
SUMMARY:BioCity Turku Guest Seminar: Prof. Shimon Sakaguchi
DESCRIPTION:12th May at 12:30\nNote the time!\nHybrid event\nin Presidentti
  auditorium\, BioCity and Zoom\nFlyer\n\nCoffee and sandwiches served at 1
 2:15\n\nNobel laureate\, Prof. Shimon Sakaguchi\, University of Osaka\, Ja
 pan\nTreg control of immune responses\, especially autoimmunity and tumor 
 immunity\n\nHost: Riitta Lahesmaa (rilahes@utu.fi)\n\nLink to join the eve
 nt online: https://utu.zoom.us/j/69149423371\n\nSakaguchi is currently a D
 istinguished Honorary Professor at the Immunology Frontier Research Center
  (IFReC) Osaka University\, Japan. He obtained an M.D. in 1976 and a Ph.D.
  in 1982 from Kyoto University\, Japan\, where he was trained as a patholo
 gist and immunologist. After performing postdoctoral studies at Johns Hopk
 ins University and Stanford University as a Lucille P. Markey Scholar\, he
  served as an Assistant Professor in the Department of Immunology at the S
 cripps Research Institute. He returned to Japan in 1991 and continued his 
 immunology research as the Head of the Department of Immunopathology at To
 kyo Metropolitan Institute of Gerontology\, Tokyo. From 1998 to 2011\, he 
 was a Professor of Institute for Frontier Medical Sciences Kyoto Universit
 y and served as the Director of the Institute from 2007 to 2011. In 2011\,
  his lab moved to Osaka University. He was elected to Foreign Member of Na
 tional Academy of Sciences USA in 2012\, and has been awarded many interna
 tional prizes including Cancer Research Institute’s William B. Coley Awa
 rd in 2004\, Keio Medical Science Prize in 2008\, Canada Gairdner Internat
 ional Award in 2015\, the Crafoord Prize in 2017\, the German Immunology A
 ward in 2019\, the Paul Ehrlich and Ludwig Darmstaedter Prize in 2020\, th
 e Robert Koch Prize in 2020\, and Debrecen Award for Molecular Medicine in
  2023\, and the Nobel Prize for Physiology or Medicine in 2025. He receive
 d an honorary degree from the University of Birmingham\, UK\, in 2019\, th
 e Medal with Purple Ribbon from the Government of Japan in 2009\, and the 
 Order of Culture\, the highest accolade for Japanese scholars of humanitie
 s and natural sciences\, from the Emperor of Japan in 2019.\n\n&nbsp\;\n\n
 Selected publications\n\nTanaka A\, Sakaguchi S. T Cell Receptor Signaling
  and Immune Tolerance: From Autoimmunity to Cancer Immunity. Annu Rev Immu
 nol. 2026 Mar 2. doi: 10.1146/annurev-immunol-082724-025403.\n\nOsaki M\, 
 Sakaguchi S. Soluble CTLA-4 regulates immune homeostasis and promotes reso
 lution of inflammation by suppressing type 1 but allowing type 2 immunity.
  Immunity. 2025 Mar 26:S1074-7613(25)00123-2. doi: 10.1016/j.immuni.2025.0
 3.004.\n\nIchiyama K\, Long J\, Kobayashi Y\, Horita Y\, Kinoshita T\, Nak
 amura Y\, Kominami C\, Georgopoulos K\, Sakaguchi S. Transcription factor 
 Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and l
 imit autoimmunity and anti-tumor immunity. Immunity. 2024 Jul 30:S1074-761
 3(24)00359-5. doi: 10.1016/j.immuni.2024.07.010.\n\nTay C\, Tanaka A\, Sak
 aguchi S. Tumor-infiltrating regulatory T cells as targets of cancer immun
 otherapy. Cancer Cell. 2023 Mar 13\;41(3):450-465. doi: 10.1016/j.ccell.20
 23.02.014.\n\nKidani Y\, Nogami W\, Yasumizu Y\, Kawashima A\, Tanaka A\, 
 Sonoda Y\, Tona Y\, Nashiki K\, Matsumoto R\, Hagiwara M\, …\, Mori M\, 
 Doki Y\, Ohkura N\, Sakaguchi S. CCR8-targeted specific depletion of clona
 lly expanded Treg cells in tumor tissues evokes potent tumor immunity with
  long-lasting memory. Proc Natl Acad Sci U S A. 2022 Feb 15\;119(7):e21142
 82119. doi: 10.1073/pnas.2114282119.
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CATEGORIES:BiocityTurku events
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