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UID:232@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20171004T120000
DTEND;TZID=Europe/Helsinki:20171004T130000
DTSTAMP:20231013T061351Z
URL:https://biocityturku.fi/events/regulation-of-oncogenic-ras-by-alternat
 ive-polyadenylation-and-micrornas/
SUMMARY:Regulation of oncogenic Ras by alternative polyadenylation and micr
 oRNAs
DESCRIPTION:Prof. W. Brent Derry\, The Hospital for Sick Children and Depar
 tment of Molecular Genetics\, University of Toronto\n\nHost: Annika Meinan
 der (ÅAU Cell Biology and Receptor Programme)\n\nThe broad goal of Derry'
 s research is to understand how genes that are mutated in various diseases
  function in vivo. He uses the powerful genetics and functional genomics t
 ools of the model organism Caenorhabditis elegans to understand how tumou
 r suppressors and oncogenes control cell survival\, genome stability and o
 rganism development. He is particularly interested in how cells communica
 te with one another to sculpt organs and make life or death decisions when
  challenged with stresses\, such as chemotherapy and radiation. Derry also
  has a robust research program that is focused on understanding the mecha
 nistic basis of the human neurovascular disease cerebral cavernous malform
 ations (CCM). He is collaborating with an international team of scientist
 s and clinicians to discover drugs that can be used to prevent the onset o
 f CCM in humans.\n\nSelected publications:\nPal\, S.\, Lant\, B.\, Yu\, B.
 \, Tian\, R.\, Tong\, J.\, Krieger\, J.R.\, Moran\, M.F.\, Gingras\, A.C.\
 , &amp\; Derry\, W. B. CCM-3 Promotes C. elegans germline development by r
 egulating vesicle trafficking cytokinesis and polarity. (2017) Current Bi
 ology. 27(6): 868-876.\n\nEroglu\, M. &amp\; Derry\, W.B. (2016) Your neig
 hbours matter – non-autonomous control of apoptosis in development and d
 isease. Cell Death and Differentiation. 23(7): 1110-1118.\n\nMateo\, A.R\,
  Kessler\, Z.\, Jolliffe\, A.K.\, McGovern\, O.\, Yu\, B.\, Nicolucci\, A.
 \, Yanowitz\, J.L. &amp\; Derry\, W.B. (2016) The p53-like protein CEP-1 i
 s required for meiotic fidelity in C. elegans. Current Biology. 26(9): 11
 48-1158.\n\nLant B\, Yu B\, Goudreault M\, Holmyard D\, Knight JD\, Xu P\,
  Zhao L\, Chin K\, Wallace E\, Zhen M\, Gingras AC\, Derry WB. (2015) CCM-
 3/STRIPAK promotes seamless tube extension through endocytic recycling. N
 ature Communications. 6: 6449.\n\nBaruah\, A.\, Chang\, H.\, Hall\, M.\, Y
 uan\, J.\, Gordon\, S.\, Johnson\, E.\, Shtessel\, L.L.\, Yee\, C.\, Hekim
 i\, S.\, Derry\, W.B.\, &amp\; Lee\, S.S. (2014). CEP1\, the Caenorhabditi
 s elegans p53 homolog\, mediates opposing longevity outcomes in mitochond
 rial electron transport chain mutants. PLoS Genetics. 10(2): e1004097.\n\n
 Perrin\, A.J.\, Gunda\, M.\, Yu\, B.\, Yen\, K.\, Ito\, S.\, Forster\, S.\
 , Young\, J.\, Tissenbaum\, H.A. &amp\; Derry\, W.B. (2013). Noncanonical 
 control of C. elegans germline apoptosis by the insulin/IGF-1 and Ras/MAP
 K signaling pathways. Cell Death and Differentiation. 20(1): 97-107.\n\nRo
 ss\, A.J.\, Li\, M.\, Yu\, B.\, Gao\, M.X. &amp\; Derry\, W.B. (2011). The
  EEL-1 ubiquitin ligase promotes DNA damage-induced germ cell apoptosis in
  C. elegans. Cell Death and Differentiation. 18(7): 1140-1149.\n\nIto\, S.
 \, Greiss\, S.\, Gartner\, A. &amp\; Derry\, W.B. (2010). Cell-nonautonomo
 us regulation of C. elegans germ cell death by kri-1. Current Biology. 20(
 4): 333-338.\n\nGao\, X. Liao\, E.\, Yu\, B.\, Wang\, Y.\, Zhen\, M. &amp\
 ; Derry\, W.B. (2008). The SCFFSN-1 ubiquitin ligase controls CEP-1/p53-de
 pendent apoptosis in Caenorhabditis elegans. Cell Death and Differentiatio
 n. 15(6): 1054-1062.\n\nQuevedo\, C.\, Kaplan\, D.R. &amp\; Derry\, W.B. 
 (2007). AKT-1 regulates DNA-damage induced germline apoptosis in C. elegan
 s. Current Biology. 17(3): 286-292.
CATEGORIES:BiocityTurku events,Other events
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