BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN BEGIN:VEVENT UID:235@biocityturku.fi DTSTART;TZID=Europe/Helsinki:20191129T100000 DTEND;TZID=Europe/Helsinki:20191129T110000 DTSTAMP:20231013T061352Z URL:https://biocityturku.fi/events/receptor-seminar-the-morphodynamics-of- metastatic-cancer-cells/ SUMMARY:Receptor seminar: The Morphodynamics of Metastatic Cancer Cells DESCRIPTION:Prof Chris Bakal Institute of Cancer Research\, London\, UK\nTh e Morphodynamics of Metastatic Cancer Cells \n\nHost: Johanna Ivaska\n\nCh ris Bakal is Professor of Cancer Morphodynamics and Team Leader in the Div ision of Cancer Biology at the Chester Beatty Laboratories\, Institute of Cancer Research (ICR). He performed graduate work in Medical Biophysics a t the University of Toronto - where he studied the regulation of microtubu les in cancer cells\, and performed collaborative work with the laboratory of Josef Penninger on the dynamics of immune synapse formation. In 2005\, he began postdoctoral work with Norbert Perrimon at Harvard Medical Schoo l and the Howard Hughes Medical Institute. In 2006\, he became an affiliat e of the Broad Institute of MIT and Harvard\, and of the Computer Science and Artificial Intelligence Laboratory (CSAIL) at MIT. While at Harvard\, Dr Bakal worked with a number of groups\, including those of George Churc h\, Bonnie Berger\, and Mike Yaffe to develop different computational tech nologies to understand the signaling networks that control cell shape dete rmination. After being awarded a Wellcome Trust Career Development Fellows hip\, Chris established his laboratory at the ICR in 2009. Currently a Can cer Research UK Stand Up to Cancer Programme Foundation Award supports Chr is’s laboratory. In 2019\, Chris was made a Professor of Cancer Morphody namics at the University of London.\n\nAs a postdoctoral fellow\, Dr. Baka l was awarded the Dorsett L. Spurgeon Award as the top postdoctoral fellow or junior faculty member at Harvard Medical School. In 2009\, he received an Outstanding Research Award from Nature Biotechnology. While at the ICR \, Chris was named one of the top 2 young investigators by the European As sociation for Cancer Research in 2011. In 2013\, he was awarded the Astra Zeneca Frank Rose Prize as the United Kingdom’s top young cancer researc her. In 2014\, he was awarded the Merrimack Pharmaceuticals Prize in Syste ms Biology by the Council of Systems Biology. In 2015\, Chris was awarded the Cancer Research UK Future Leaders Prize\n\nOutside of science Chris is a competitive track cyclist\, and a former world-ranked downhill ski race r.\n\n \;\n\nSelected recent publications:\nHeldt FS\, Barr AR\, Coope r S\, Bakal C\, Novák B. A comprehensive model for the proliferation-quie scence decision in response to endogenous DNA damage in human cells. Proc Natl Acad Sci U S A. 2018 Mar 6\;115(10):2532-2537. doi: 10.1073/pnas.1715 345115.\n\nSanchez-Alvarez M\, Bakal C. PERK links the clock and protein s tress in cancer. Nat Cell Biol. 2018 Jan\;20(1):4-5. doi: 10.1038/s41556-0 17-0019-6.\n\nSanchez-Alvarez M\, Del Pozo MA\, Bakal C. AKT-mTOR signalin g modulates the dynamics of IRE1 RNAse activity by regulating ER-mitochond ria contacts. Sci Rep. 2017 Nov 28\;7(1):16497.\n\nBarr AR\, Cooper S\, He ldt FS\, Butera F\, Stoy H\, Mansfeld J\, Novák B\, Bakal C. DNA damage d uring S-phase mediates the proliferation-quiescence decision in the subseq uent G1 via p21 expression. Nat Commun. 2017 Mar 20\;8:14728. doi: 10.1038 /ncomms14728.\n\nAsghar US\, Barr AR\, Cutts R\, Beaney M\, Babina I\, Sam path D\, Giltnane J\, Lacap JA\, Crocker L\, Young A\, Pearson A\, Herrera -Abreu MT\, Bakal C\, Turner NC. Single-Cell Dynamics Determines Response to CDK4/6 Inhibition in Triple-Negative Breast Cancer. Clin Cancer Res. 20 17 Sep 15\;23(18):5561-5572. doi: 10.1158/1078-0432.CCR-17-0369.\n\nCooper S\, Bakal C. Accelerating Live Single-Cell Signalling Studies. Trends Bio technol. 2017 May\;35(5):422-433. doi: 10.1016/j.tibtech.2017.01.002.\n\nS ailem HZ\, Bakal C. Identification of clinically predictive metagenes that encode components of a network coupling cell shape to transcription by im age-omics. Genome Res. 2017 Feb\;27(2):196-207. doi: 10.1101/gr.202028.115 . CATEGORIES:BiocityTurku events LOCATION:#_LOCATIONNAME\, #_LOCATIONFULLLINE\, #_LOCATIONCOUNTRY X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=#_LOCATIONFULLLINE\, #_LOCA TIONCOUNTRY;X-APPLE-RADIUS=100;X-TITLE=#_LOCATIONNAME:geo:0,0 END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20191027T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR