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UID:239@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20180920T130000
DTEND;TZID=Europe/Helsinki:20180920T140000
DTSTAMP:20231013T061353Z
URL:https://biocityturku.fi/events/receptor-seminar-mycn-metabolism-and-di
 fferentiation-in-childhood-neuroblastoma/
SUMMARY:Receptor seminar: MYCN\, metabolism and differentiation in childhoo
 d neuroblastoma
DESCRIPTION:Professor Marie Arsenian-Henriksson (Karolinska Institutet\, S
 weden)\n\nHost: Jukka Westermarck (jukka.westermarck@utu.fi)\n\nCoffee and
  sweet pastries are served at 12:45\n\n&nbsp\;\n\nPhD from Karolinska Inst
 itutet (KI) during 1993 with Professor Georg Klein as supervisor. Assistan
 t Professor at the Department of Microbiology\, Tumor and Cell Biology (MT
 C) in KI since 1997 with focus on the MYC oncogene and childhood neuroblas
 toma. Associate Professor in Tumor Biology since 2001. Department Head 200
 6-2016. Senior Investigator Award from the Swedish Cancer Society 2007. Pr
 ofessor at KI since 2010. Sabbatical in the laboratory of Robert Eisenman\
 , the Fred Hutchinson Cancer Research Center in Seattle\, USA during 2016.
 \n\nSelected publications\n\n 	Dzieran J\, Rodriguez Garcia A\, Westermark
  UK\, Henley AB\, Eyre Sánchez E\, Träger C\, Johansson HJ\, Lehtiö J\,
  and Arsenian Henriksson M. MYCN-amplified neuroblastoma maintains an ag
 gressive and undifferentiated phenotype by deregulation of estrogen and NG
 F signaling.Proc. Natl. Acad. Sci. USA115(6): E1229-E1238 (2018)\n 	Fell S
 M\, Li S\, Wallis K\, Surova O\,Raklli V\, Höfig C\, Mittag J\,Arsenian 
 Henriksson M\, Kenchappa RS\, Holmberg J\, Kogner P and Schlisio S. KIF
 1Bβ links neuroblastoma and neurodegenerative disease through anterograde
  transport of TRKA. Genes &amp\; DevelopmentMay 15\;31(10):1036-1053 (20
 17).\n 	Ribeiro D\, Klarqvist MDR\, Westermark\, KU\, Oliynyk G\, Dzieran 
 J\, Savatier Banares C\, Kock A\, Hertwig F\, Johansen JI\, Fischer M\, Ko
 gner P\, Lovén J\,and Arsenian Henriksson\, M. Regulation of the nuclear
  hormone receptor family by MYCN-driven miRNAs affects differentiation and
  survival in neuroblastoma. Cell Reports16(4)\, 979-93 (2016).\n 	Zinin N
 \, Adameyko I\, Wilhelm M\, Fritz N\, Uhlén P\, Ernfors P\, ArsenianHenr
 iksson M.MYC Proteins Promote Neuronal Differentiation by Controlling the 
 Mode of Progenitor Cell Division. EMBO Reports15(4): 383-91(2014).\n 	Zir
 ath H\, Frenzel A\, Oliynyk G\, Segerström L\, Westermark U\, Larsson K\,
  Munksgaard Persson M\, Hultenby K\, Lethio J\, Einvik C\, Påhlman S\, Ko
 gner P\, Jakobsson PJ\, and Arsenian Henriksson\, M. MYC inhibition indu
 ces metabolic changes leading to accumulation of lipid droplets in tumor c
 ells. Proc Natl Acad Sci USA110(25): 10258-63 (2013).\n\n&nbsp\;
CATEGORIES:BiocityTurku events
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BEGIN:VTIMEZONE
TZID:Europe/Helsinki
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DTSTART:20180325T040000
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