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UID:240@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20180816T110000
DTEND;TZID=Europe/Helsinki:20180816T120000
DTSTAMP:20231013T061354Z
URL:https://biocityturku.fi/events/receptor-seminar-mechanisms-and-interve
 ntions-for-defective-intermediate-filament-proteostasis/
SUMMARY:Receptor seminar: Mechanisms and Interventions for Defective Interm
 ediate Filament Proteostasis
DESCRIPTION:Assistant prof. Natasha Snider\, University of North Caroline\,
  Chapel Hill\, NC\, USA\n\nHost: Diana Toivola (dtoivola@abo.fi)\n\n\nDr. 
 Snider’s reserach is focused on the molecular basis of liver diseases an
 d disorders linked to intermediate filament gene mutations. Her team uses 
 biochemical\, cell-based and in vivo approaches to identify potential dise
 ase targets and to understand their function and regulation.\n\nTheir majo
 r goals are to promote the discovery of pharmacological agents that can sl
 ow or halt the progression of these diseases. The liver-related studies ha
 s linked liver injury susceptibility to the function of energy metabolism 
 regulators\, including the glycolytic enzyme GAPDH and the purine metaboli
 zing enzymes nucleoside diphosphate kinase (NDPK) and ecto-5'-nucleotidase
  CD73.  Their aims are to understand the regulation and cell-specific fun
 ctions of CD73 in various stages of liver disease\, including fibrosis\, c
 irrhosis and hepatocellular carcinoma. \n\nAnother research interest is in
  the area of intermediate filaments and related diseases. Intermediate fil
 ament gene mutations are linked to a vast number of human pathologies\, in
 cluding skin fragility disorders\, neuropathies\, myopathies\, liver disea
 ses\, metabolic dysfunctions\, and premature aging syndromes. Effective tr
 eatments for diseases caused by intermediate filament gene mutations are l
 acking. The long-term goals are to define the proteostasis network of inte
 rmediate filament proteins and to identify key features compromised by dis
 ease-causing or disease-promoting mutations. A central research focus is o
 n various post-translational modifications and their cross-talk mechanisms
 .\n\nSelected publications\n\nTrogden KP\, Battaglia RA\, Kabiraj P\, Madd
 en VJ\, Herrmann H\, Snider NT (2018). An image-based small molecule scree
 n identifies vimentin as a pharmacologically relevant target of simvastati
 n in cancer cells. FASEB J. 32(5):2841-2854. \n\nBattaglia RA\, Kabiraj P\
 , Willcockson HH\, Lian M\, Snider NT. (2017) Isolation of Intermediate Fi
 lament Proteins from Multiple Mouse Tissues to Study Aging-associated Post
 -translational Modifications. J Vis Exp. (123). doi: 10.3791/55655. \n\nSn
 ider NT\, Altshuler PA\, Omary MB. (2015). Modulation of cytoskeletal dyna
 mics by mammalian nucleoside diphosphate kinase (NDPK) proteins. Naunyn Sc
 hmiedebergs Arch Pharmacol. 388(2):189-197.\n\nSnider NT and Omary MB (201
 6). Assays for post-translational modifications of intermediate filament p
 roteins. Methods in Enzymology: Intermediate Filaments. 568:113-138.\n\nSn
 ider NT and Omary MB (2014). Post-translational modifications of intermedi
 ate filament proteins: function and regulation. Nat Rev Mol Cell Biol. 15:
 163-177.
CATEGORIES:BiocityTurku events
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TZID:Europe/Helsinki
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DTSTART:20180325T040000
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