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UID:241@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20200220T120000
DTEND;TZID=Europe/Helsinki:20200220T130000
DTSTAMP:20231013T061354Z
URL:https://biocityturku.fi/events/receptor-seminar-illuminating-notch-and
 -wnt-signaling-mechanisms-through-protein-engineering/
SUMMARY:Receptor seminar: Illuminating Notch and Wnt signaling mechanisms t
 hrough protein engineering
DESCRIPTION:Vincent C. Luca\, PhD\, Moffitt Cancer Center &amp\; University
  of South Florida\nIlluminating Notch and Wnt signaling mechanisms through
  protein engineering\n\nHost: Cecilia Sahlgren (cecilia.sahlgren@abo.fi)\n
 \nCoffee and sandwiches at 11:45\n\nAbstract\nHuman development is orchest
 rated by cell surface receptors that sense and respond to dynamic molecula
 r signals. Among the ~20\,000 protein-coding genes in the human genome\, i
 t has been determined that a remarkably small number of conserved signalin
 g systems (Notch\, Wnt\, Shh\, Jak/Stat\, RTK\, TGF-β\, NF-κB) control t
 he vast majority of cell fate decisions. In accord with their central imp
 ortance in human biology\, dysregulation of these “professional” devel
 opmental pathways contributes to the pathogenesis of congenital diseases a
 nd cancer.\n\nMy group integrates approaches in structural biology\, cellu
 lar biology\, and protein engineering to study developmental receptor sign
 aling. We are particularly interested in understanding how mechanosensitiv
 e Notch receptors are activated by their ligands Jagged (Jag) and Delta-li
 ke (DLL). To approach this problem\, we determined high-resolution structu
 res of Notch receptor-ligand complexes\, which provided insight into the r
 oles of molecular tension and receptor glycosylation as regulatory mechani
 sms. We are now using various engineering strategies to develop targeted N
 otch agonists and antagonists as cancer drugs. In addition to our work on 
 Notch\, we are employing synthetic biology-based approaches to modulate Wn
 t signaling for applications in regenerative medicine. The collective goal
  of our research is to reprogram developmental signaling to pave the way f
 or the development of next-generation therapies\n\nSelected publications\n
 Luca VC et al.\, Surrogate R-spondins for tissue-specific potentiation of
  Wnt Signaling. PlosOne 2020\n\nMing Q et al.\, Molecular engineering stra
 tegies for visualizing low-affinity protein complexes. Exp Biol Med (Maywo
 od) 2019\n\nSchneider et al.\, Inhibition of Delta-induced Notch signali
 ng using fucose analogs. Nat Chem Biol 2018.\nHighlighted: Notch signaling
  a sweet strategy. Nat Chem Biol 2018\n\nLuca VC et al.\, 2017 Notch-Jagge
 d complex structure implicates a catch bond in tuning ligand sensitivity. 
 Science 2017\nHighlighted: Signal Transduction: Notch Catches a Jagged edg
 e. Nat Chem Biol 2017\n\nYan et al.\, Non-equivalence of Wnt and R-spondin
  ligands during Lgr5+ intestinal stem-cell self-renewal. Nature 2017\nHig
 hlighted: R-spondin is more than just Wnt’s Sidekick . Dev Cell 2017\n\n
 Luca VC et al.\, Structural basis for Notch1 engagement of Delta-like 4. S
 cience 2015
CATEGORIES:BiocityTurku events
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TZID:Europe/Helsinki
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BEGIN:STANDARD
DTSTART:20191027T030000
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TZOFFSETTO:+0200
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