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UID:243@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20180412T130000
DTEND;TZID=Europe/Helsinki:20180412T140000
DTSTAMP:20231013T061354Z
URL:https://biocityturku.fi/events/receptor-seminar-endothelial-cell-proge
 nitors-high-endothelial-venules-adn-the-immune-response/
SUMMARY:Receptor seminar: Endothelial cell progenitors\, high endothelial v
 enules and the immune response
DESCRIPTION:Dr. Eugene Butcher\, Klaus Bensch Professor of Pathology\, Sta
 nford University School of Medicine\, Laboratory of Immunology and Vascula
 r Biology\, Palo Alto VA Medical Center\, US\n\nHost: Sirpa Jalkanen (sirp
 a.jalkanen@utu.fi)\n\n&nbsp\;\n\nProf. Butcher and his collaborators have 
 made fundamental discoveries on cell-cell recognition\, migration and deve
 lopment by using the mammalian immune system as a model. His work has been
  cited about 58 000 times and his H-index is 135 (web of science). His la
 b is using state-of-the-art molecular and genetic approaches\, such as CyT
 OF to study the development and trafficking of white blood cells (e.g. lym
 phocytes\, dendritic cells)\, including their interactions with the endoth
 elial lining of blood vessels at sites of leukocyte extravasation\, their 
 chemotactic responses in tissues\, and their programming by environmental 
 factors in lymphoid tissues and within mucosal surfaces.\n\nThe Butcher la
 boratory applies these findings of fundamental biological problems to tran
 slational contexts\, such as therapeutic manipulation of immune cell traff
 icking\, for example in models of colitis\, multiple sclerosis\, atheroscl
 erosis and psoriasis. Targets and insights from the lab's research have le
 d to clinical stage antibody and small molecule therapeutics for inflammat
 ory bowel disease.\n\nProf. Butcher laboratory web page: http://butcherla
 b.stanford.edu\n\nSelected publications\n\nTrafficking receptor signatures
  define blood plasmablasts responding to tissue-specific immune challenge.
 \nSeong Y\, Lazarus NH\, Sutherland L\, Habtezion A\, Abramson T\, He XS\,
  Greenberg HB\, Butcher EC. JCI Insight. 2017 Mar 23\;2(6)\n\nLeukocyte 
 chemoattractant receptors in human disease pathogenesis.\nZabel BA\, Rott 
 A\, Butcher EC\, Annu Rev Pathol. 2015\;10:51-81.\n\nTranscriptional pro
 grams of lymphoid tissue capillary and high endothelium reveal control mec
 hanisms for lymphocyte homing.\nLee M\, Kiefel H\, LaJevic MD\, Macauley M
 S\, Kawashima H\, O'Hara E\, Pan J\, Paulson JC\, Butcher EC. Nature immu
 nol. 2014\;15(10):982-95.\n\nComparative transcriptional and functional pr
 ofiling defines conserved programs of intestinal DC differentiation in hum
 ans and mice.\nWatchmaker PB\, Lahl K\, Lee M\, Baumjohann D\, Morton J\, 
 Kim SJ\, Zeng R\, Dent A\, Ansel KM\, Diamond B\, Hadeiba H\, Butcher EC.\
 , Nature Immunol. 2014 Jan\;15(1):98-108.
CATEGORIES:BiocityTurku events
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TZID:Europe/Helsinki
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BEGIN:DAYLIGHT
DTSTART:20180325T040000
TZOFFSETFROM:+0200
TZOFFSETTO:+0300
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