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UID:246@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20190819T110000
DTEND;TZID=Europe/Helsinki:20190819T120000
DTSTAMP:20231013T061534Z
URL:https://biocityturku.fi/events/receptor-seminar-actin-on-transcription
 /
SUMMARY:Receptor seminar: Actin' on Transcription
DESCRIPTION:Receptor Programme Seminar\n\nAdj. Prof. Maria Vartiainen\, Ins
 titute of Biotechnology\, University of Helsinki\nActin' on Transcription 
 \n\nHost: Jukka Ali-Nikula (juilal@utu.fi)\n\nMaria Vartiainen studied mo
 lecular biology at the University of Jyväskylä\, and obtained her MSc in
  1999. She did her PhD thesis with Pekka Lappalainen at the Institute of B
 iotechnology (BI)\, graduating in 2002.  After this Maria worked as a pos
 t-doc funded by the EMBO Long Term Fellowship in the lab of Richard Treism
 an at London Research Institute of Cancer Research UK 2003-2007. There she
  developed interest in nuclear functions of actin especially in regulating
  gene expression. Maria returned to BI in 2007 as a group leader\, and is 
 currently also the scientific leader of the Light Microscopy Unit (LMU) at
  BI. Her laboratory wants to understand the mechanisms by which actin oper
 ates in the nucleus to regulate essential nuclear events\, such as gene ex
 pression and maintenance of genomic integrity. She is especially intereste
 d in the role of actin in transcription by RNA polymerase II\, and her stu
 dies have shown that actin interacts with virtually all transcribed genes.
 \n\nSelected publications\nViita T\, Kyheröinen S\, Prajapati B\, Virtane
 n J\, Varjosalo M\, Vartiainen MK. Nuclear actin interactome analysis link
 s actin to KAT14 histone acetyl transferase and mRNA splicing. J Cell Sci 
 2019\n\nSokolova M\, Moore HM\, Prajapati B\, Dopie J\, Merilainen L\, Hon
 kanen M\, Matos RC\, Poukkula M\,  Hietakangas V\, Vartiainen MK Nuclear 
 actin is required for transcription during Drosophila oogenesis iScience 2
 018 Nov 30\;9:63-70.\n\nNevzorov I\, Sidorenko E\, Wang W\, Zhao H\, Varti
 ainen MK. Myosin-1C uses a novel phosphoinositide-dependent pathway for nu
 clear localization. EMBO Rep. 2018 Feb\;19(2):290-304.\n\nMoore HM\, Varti
 ainen MK. F-actin organizes the nucleus. Nat Cell Biol. 2017 Nov 29\;19(12
 ):1386-1388\n\nKristó I\, Bajusz C\, Borsos BN\, Pankotai T\, Dopie J\, J
 ankovics F\, Vartiainen MK\, Erdélyi M\, Vilmos P. The actin binding cyto
 skeletal protein Moesin is involved in nuclear mRNA export. Biochim Biophy
 s Acta. 2017 Oct\;1864(10):1589-1604.\n\nVirtanen JA\, Vartiainen MK. Dive
 rse functions for different forms of nuclear actin. Curr Opin Cell Biol. 2
 017 Jun\;46:33-38.\n\nRajakylä EK\, Viita T\, Kyheröinen S\, Huet G\, Tr
 eisman R\, Vartiainen MK. RNA export factor Ddx19 is required for nuclear 
 import of the SRF coactivator MKL1. Nat Commun. 2015 Jan 14\;6:5978.\n\nHu
 et G\, Rajakylä EK\, Viita T\, Skarp KP\, Crivaro M\, Dopie J\, Vartiaine
 n MK. Actin-regulated feedback loop based on Phactr4\, PP1 and cofilin mai
 ntains the actin monomer pool.  J Cell Sci. 2013 Jan 15\;126(Pt 2):497-50
 7.\n\nDopie J\, Skarp KP\, Rajakylä EK\, Tanhuanpää K\, Vartiainen MK. 
 Active maintenance of nuclear actin by importin 9 supports transcription. 
 Proc Natl Acad Sci U S A. 2012 Feb 28\;109(9):E544-52\n\n&nbsp\;
CATEGORIES:BiocityTurku events
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