BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.3.3//EN BEGIN:VEVENT UID:247@biocityturku.fi DTSTART;TZID=Europe/Helsinki:20180830T120000 DTEND;TZID=Europe/Helsinki:20180830T130000 DTSTAMP:20231013T061535Z URL:https://biocityturku.fi/events/receptor-seminar-actin-based-motility-i n-cancer-invasion-and-metastasis/ SUMMARY:Receptor Seminar: Actin-based motility in cancer invasion and metas tasis DESCRIPTION:Prof. Laura Machesky\, The Beatson Institute\, Glasgow\, UK\n\n Host: Jeroen Pouwels (jeroen.pouwels@utu.fi)\nIf you would like to meet Pr of. Machesky on 30.8. to discuss your newest exciting data\, please contac t the host.\n\n \;\n\nProf. Machesky´s lab (http://www.beatson.gla.ac .uk/Invasion-and-Metastasis/laura-machesky-migration-invasion-and-metastas is.html) aims to understand the control and mechanisms of actin assembly i n various normal and cancer cells with the hope to understand fundamental aspects of cell movement. Besides using cell culture\, her lab employs sev eral clinically relevant cancer models\, mostly in mice\, and she collabor ates with many other research groups. She has made several seminal discove ries in the field\, as evident from her publication list (see below for so me of her recent papers) and honors. She did her PhD in the lab of the leg endary Prof. Pollard in The Johns Hopkins School of Medicine\, where\, am ong other things\, she was (one of) the first to report the Arp2/3 complex . After having had her lab for 8 years at the University of Birmingham\, s he moved to the Beatson in 2007 and has been there ever since.\n\nSelected publications\n\nMorris HT\, Fort L\, Spence HJ\, Patel R\, Vincent DF\, P ark JH\, Snapper SB\, Carey FA\, Sansom OJ\, Machesky LM. Loss of N-WASP d rives early progression in an Apc model of intestinal tumourigenesis. J Pa thol 2018\; 245: 337-48 doi: 10.1002/path.5086\n\nGiampazolias E\, Zunino B\, Dhayade S\, Bock F\, Cloix C\, Cao K\, Roca A\, Lopez J\, Ichim G\, P roics E\, Rubio-Patino C\, Fort L\, Yatim N\, Woodham E\, Orozco S\, Tarab orrelli L\, Peltzer N\, Lecis D\, Machesky L\, Walczak H et al. Mitochondr ial permeabilization engages NF-kappaB-dependent anti-tumour activity unde r caspase deficiency. Nat Cell Biol 2017\; 19: 1116-29\n\nReid SE\, Kay EJ \, Neilson LJ\, Henze AT\, Serneels J\, McGhee EJ\, Dhayade S\, Nixon C\, Mackey JB\, Santi A\, Swaminathan K\, Athineos D\, Papalazarou V\, Patella F\, Roman-Fernandez A\, ElMaghloob Y\, Hernandez-Fernaud JR\, Adams RH\, Ismail S\, Bryant DM et al. Tumor matrix stiffness promotes metastatic can cer cell interaction with the endothelium. EMBO J 2017\; 36: 2373-89\n\nGa rcia E\, Ragazzini C\, Yu XZ\, Cuesta-Garcia E\, de la Serna JB\, Zech T\, Sarrio D\, Machesky LM\, Anton IM. WIP and WICH/WIRE co-ordinately contro l invadopodium formation and maturation in human breast cancer cell invasi on. Sci Rep 6: 23590\, 2016\n\nRainero E\, Howe JD\, Caswell PT\, Jamieson NB\, Anderson K\, Critchley DR\, Machesky L\, Norman JC. Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration. C ell Rep 2015. doi: 10.1016/j.celrep.2014.12.037. Epub 2015 Jan 15\n\nLi A\ , Morton JP\, Ma Y\, Karim SA\, Zhou Y\, Faller WJ\, Woodham EF\, Morris H T\, Stevenson RP\, Juin A\, Jamieson NB\, MacKay CJ\, Carter CR\, Leung HY \, Yamashiro S\, Blyth K\, Sansom OJ\, Machesky LM. Fascin is regulated by slug\, promotes progression of pancreatic cancer in mice\, and is associa ted with patient outcomes. Gastroenterology 146: 1386-96 e1-17\, 2014\n\nL i A\, Ma Y\, Yu X\, Mort RL\, Lindsay CR\, Stevenson D\, Strathdee D\, Ins all RH\, Chernoff J\, Snapper SB\, Jackson IJ\, Larue L\, Sansom OJ\, Mach esky LM. Rac1 Drives Melanoblast Organization during Mouse Development by Orchestrating Pseudopod- Driven Motility and Cell-Cycle Progression. Dev C ell 21: 722- 34\, 2011\n\nZech T\, Calaminus SDJ\, Caswell PT\, Spence HJ\ , Carnell MJ\, Insall RH\, Norman JC\, Machesky LM. The Arp2/3 activator W ASH regulates alpha-5 beta-1 integrin mediated invasive migration. J Cell Sci 124(Pt 22): 3753-9\, 2011\n\nLi A\, Dawson JC\, Forero-Vargas M\, Spen ce HJ\, Yu X\, Konig I\, Anderson K\, Machesky LM. The actin-bundling prot ein fascin stabilizes actin in invadopodia and potentiates protrusive inva sion. Curr Biol 20: 339-45\, 2010\n\n \;\n\n \;\n\n \; CATEGORIES:BiocityTurku events LOCATION:#_LOCATIONNAME\, #_LOCATIONFULLLINE\, #_LOCATIONCOUNTRY X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=#_LOCATIONFULLLINE\, #_LOCA TIONCOUNTRY;X-APPLE-RADIUS=100;X-TITLE=#_LOCATIONNAME:geo:0,0 END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20180325T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR