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UID:249@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20180412T130000
DTEND;TZID=Europe/Helsinki:20180412T140000
DTSTAMP:20231013T061535Z
URL:https://biocityturku.fi/events/receptor-programme-seminar-endothelial-
 cell-progenitors-high-endothelial-venules-and-the-immune-response/
SUMMARY:Receptor programme seminar: Endothelial cell progenitors\, high end
 othelial venules and the immune response
DESCRIPTION:Dr. Eugene Butcher\, Klaus Bensch Professor of Pathology\, Sta
 nford University School of Medicine\, Laboratory of Immunology and Vascula
 r Biology\, Palo Alto VA Medical Center\n\nHost: Sirpa Jalkanen\n\n&nbsp\;
 \n\nProf. Butcher and his collaborators have made fundamental discoveries 
 on cell-cell recognition\, migration and development by using the mammalia
 n immune system as a model. His work has been cited about 58 000 times and
  his H-index is 135 (web of science). His lab is using state-of-the-art m
 olecular and genetic approaches\, such as CyTOF to study the development a
 nd trafficking of white blood cells (e.g. lymphocytes\, dendritic cells)\,
  including their interactions with the endothelial lining of blood vessels
  at sites of leukocyte extravasation\, their chemotactic responses in tiss
 ues\, and their programming by environmental factors in lymphoid tissues a
 nd within mucosal surfaces.\n\nThe Butcher laboratory applies these findin
 gs of fundamental biological problems to translational contexts\, such as 
 therapeutic manipulation of immune cell trafficking\, for example in model
 s of colitis\, multiple sclerosis\, atherosclerosis and psoriasis. Targets
  and insights from the lab's research have led to clinical stage antibody 
 and small molecule therapeutics for inflammatory bowel disease.\n\nProf. B
 utcher laboratory web page: http://butcherlab.stanford.edu\n\n&nbsp\;\n\n
 Selected publications\n\nTrafficking receptor signatures define blood plas
 mablasts responding to tissue-specific immune challenge.\nSeong Y\, Lazaru
 s NH\, Sutherland L\, Habtezion A\, Abramson T\, He XS\, Greenberg HB\, Bu
 tcher EC. JCI Insight. 2017 Mar 23\;2(6)\n\nLeukocyte chemoattractant re
 ceptors in human disease pathogenesis.\nZabel BA\, Rott A\, Butcher EC\,
  Annu Rev Pathol. 2015\;10:51-81.\n\nTranscriptional programs of lymphoid
  tissue capillary and high endothelium reveal control mechanisms for lymph
 ocyte homing.\nLee M\, Kiefel H\, LaJevic MD\, Macauley MS\, Kawashima H\,
  O'Hara E\, Pan J\, Paulson JC\, Butcher EC. Nature immunol. 2014\;15(10)
 :982-95.\n\nComparative transcriptional and functional profiling defines c
 onserved programs of intestinal DC differentiation in humans and mice.\nWa
 tchmaker PB\, Lahl K\, Lee M\, Baumjohann D\, Morton J\, Kim SJ\, Zeng R\,
  Dent A\, Ansel KM\, Diamond B\, Hadeiba H\, Butcher EC.\, Nature Immunol
 . 2014 Jan\;15(1):98-108.
CATEGORIES:BiocityTurku events
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TZID:Europe/Helsinki
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DTSTART:20180325T040000
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