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UID:250@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20180326T120000
DTEND;TZID=Europe/Helsinki:20180326T130000
DTSTAMP:20231013T061536Z
URL:https://biocityturku.fi/events/receptor-programme-seminar-deciphering-
 the-talin-code-understanding-mechanotransduction-using-structural-mechanob
 iology/
SUMMARY:Receptor programme seminar: Deciphering the talin code - Understand
 ing mechanotransduction using structural mechanobiology
DESCRIPTION:Dr. Ben Goult\, University of Kent\, UK\n\nHost: Johanna Ivaska
 \n\nDr. Goult is available for discussions on Monday and Tuesday (26th- 27
 th March). If you would like to meet with Dr Goult\, please contact Hellye
 h Hamidi hellham@utu.fi.\n\n \n\nDr Goult’s research is centred on a fu
 ndamental question in biology: how are mechanical stimuli from the extrace
 llular environment converted into functional signals that regulate cell be
 haviour? Current paradigms suggest that force is transduced via specialize
 d mechanosensory proteins\, which are becoming increasingly recognised as 
 potential targets for therapeutic intervention in a range of pathologies i
 ncluding cancer and vascular disorders.\n\nDr Goult’s group uses biochem
 ical and biophysical approaches (e.g. single-molecule force manipulation) 
 to understand the structure and function of these important mechanosensory
  proteins. His group’s particular interest lies in investigating the lin
 k between physiologically relevant\, force-dependent conformational change
 s in talin\, and talin function as a recognised mechanosensor and essentia
 l cytoplasmic adaptor for cell adhesion to the extracellular matrix.\n\n&n
 bsp\;\n\nSelected publications\n\nCollier MEW\, Ettelaie C\, Goult BT\, Ma
 raveyas A\, Goodall AH. Investigation of the Filamin A-Dependent Mechanism
 s of Tissue Factor Incorporation into Microvesicles. Thromb Haemost. 2017 
 Nov\;117(11):2034-2044.\n\nQi L\, Jafari N\, Li X\, Chen Z\, Li L\, Hytön
 en VP\, Goult BT\, Zhan CG\, Huang C. Talin2-mediated traction force drive
 s matrix degradation and cell invasion. J Cell Sci. 2016 Oct 1\;129(19):36
 61-3674.\n\nBouchet BP\, Gough RE\, Ammon YC\, van de Willige D\, Post H\,
  Jacquemet G\, Altelaar AM\, Heck AJ\, Goult BT\, Akhmanova A. Talin-KANK1
  interaction controls the recruitment of cortical microtubule stabilizing 
 complexes to focal adhesions. Elife. 2016 Jul 13\;5. pii: e18124.\n\nKumar
  A\, Ouyang M\, Van den Dries K\, McGhee EJ\, Tanaka K\, Anderson MD\, Gro
 isman A\, Goult BT\, Anderson KI\, Schwartz MA. Talin tension sensor revea
 ls novel features of focal adhesion force transmission and mechanosensitiv
 ity. J Cell Biol. 2016 May 9\;213(3):371-83.\n\nAtherton P\, Stutchbury B\
 , Wang DY\, Jethwa D\, Tsang R\, Meiler-Rodriguez E\, Wang P\, Bate N\, Ze
 nt R\, Barsukov IL\, Goult BT\, Critchley DR\, Ballestrem C. Vinculin cont
 rols talin engagement with the actomyosin machinery. Nat Commun. 2015 Dec 
 4\;6:10038.\n\nVillari G\, Jayo A\, Zanet J\, Fitch B\, Serrels B\, Frame 
 M\, Stramer BM\, Goult BT\, Parsons M. A direct interaction between fascin
  and microtubules contributes to adhesion dynamics and cell migration. J C
 ell Sci. 2015 Dec 15\;128(24):4601-14Goult\, B. et al. (2013). RIAM and vi
 nculin binding to talin are mutually exclusive and regulate adhesion assem
 bly and turnover. The Journal of biological chemistry [Online] 288:8238-82
 49.\n\nGoult\, B. et al. (2013). Structural studies on full-length talin1 
 reveal a compact auto-inhibited dimer: implications for talin activation. 
 Journal of structural biology [Online] 184:21-32.
CATEGORIES:BiocityTurku events
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DTSTART:20180325T040000
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