BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.4.8//EN BEGIN:VEVENT UID:986@biocityturku.fi DTSTART;TZID=Europe/Helsinki:20261111T150000 DTEND;TZID=Europe/Helsinki:20261111T160000 DTSTAMP:20261030T121421Z URL:https://biocityturku.fi/events/mist-guest-seminar-3/ SUMMARY:MIST Seminar DESCRIPTION:11th November 15:00-16:00\nOnsite event\nin Lauren 2\, Medisiin a D\n\nProf. Miguel Soares\, Gulbenkian Institute of Molecular Medicine (G IMM)\, Portugal\n"Host defence adaptations to infection"\n\nHost: António Sousa (aggode@utu.fi)\n\nCoffee and pulla served at 14:30\, first come fi rst serve!\n\nBook a session with the guest: https://seafile.utu.fi/f/54c9 30db992d4b6c9e11\n\n \;\n\nMiguel Soares is a PI at the Gulbenkian Ins titute of Molecular Medicine (GIMM) in Portugal\, where he leads the Infla mmation Laboratory (https://gimm.pt/lab/miguel-soares-lab)\, and an invite d professor at the Lisbon Medical School\, Universidade de Lisboa. He obta ined his PhD from the University of Louvain in Belgium\, did his postdocto ral training at Harvard Medical School in Boston\, and set up his lab at t he Instituto Gulbenkian de Ciência in 2004. His lab studies how organisms survive infection. Besides fighting microbes directly (resistance)\, host s can also limit the damage an infection causes without reducing the patho gen load\, a strategy known as disease tolerance. The lab investigates how stress responses and inter-organ communication rewire host metabolism to make this possible\, mainly in malaria and sepsis. Its contributions inclu de uncovering the protective roles of carbon monoxide and sickle haemoglob in in malaria\, and showing that cross-regulation of iron and glucose meta bolism establishes disease tolerance to sepsis. Most recently\, the lab ha s shown that jaundice may be a shield rather than a symptom: bilirubin acc umulation during malaria appears to be an adaptive response that helps kil l the parasite and protect host tissues. This work is now funded by his se cond ERC Advanced Grant (KILLBILL)\, which will explore bilirubin as a wea pon against the parasite\, a shield for host tissues and a modulator of im mune responses. It is also funded by the “la Caixa” Foundation to inve stigate whether bilirubin protects the kidneys of children with severe mal aria and to identify early biomarkers of acute kidney injury.\n\n \;\n \nSelected publications:\n\nPamplona A\, Ferreira A\, Balla J\, Jeney V\, Balla G\, Epiphanio S\, Chora A\, Rodrigues CD\, Gregoire IP\, Cunha-Rodri gues M\, Portugal S\, Soares MP\, Mota MM. Heme oxygenase-1 and carbon mon oxide suppress the pathogenesis of experimental cerebral malaria. Nat Med. 2007 Jun\;13(6):703-710.\n\nFerreira A\, Marguti I\, Bechmann I\, Jeney V \, Chora A\, Palha NR\, Rebelo S\, Henri A\, Beuzard Y\, Soares MP. Sickle hemoglobin confers tolerance to Plasmodium infection. Cell. 2011 Apr 29\; 145(3):398-409.\n\nMedzhitov R\, Schneider DS\, Soares MP. Disease toleran ce as a defense strategy. Science. 2012 Feb 24\;335(6071):936-941.\n\nWeis S\, Carlos AR\, Moita MR\, Singh S\, Blankenhaus B\, Cardoso S\, Larsen R \, Rebelo S\, Schäuble S\, Del Barrio L\, Mithieux G\, Rajas F\, Lindig S \, Bauer M\, Soares MP. Metabolic adaptation establishes disease tolerance to sepsis. Cell. 2017 Jun 15\;169(7):1263-1275.e14.\n\nFigueiredo A\, Ras togi ST\, …\, Portugal S\, Kurth F\, Elo LL\, Paul BD\, Martins R\, Soar es MP. A metabolite-based resistance mechanism against malaria. Science. 2 025 Jun 12\;388(6752):eadq6741. ATTACH;FMTTYPE=image/jpeg:https://biocityturku.fi/wp-content/uploads/MIST- seminar-flyer.png CATEGORIES:BiocityTurku events END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20261025T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR