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UID:761@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20250331T150000
DTEND;TZID=Europe/Helsinki:20250331T160000
DTSTAMP:20250325T110523Z
URL:https://biocityturku.fi/events/mist-guest-seminar-2/
SUMMARY:MIST Guest Seminar
DESCRIPTION:31st March at 15:00\nOnsite event\nin Säätiö sali\, Medisiin
 a D\, 1. floor\n\nMaheswara Reddy Emani\, Ph.D. Principal Scientist /Group
  Leader\, Genentech\, California\,USA.\niPSC-derived Complex models for D
 rug Discovery\n\nHost: Riitta Lahesmaa (rilahes@utu.fi)\n\n&nbsp\;\n\nMahe
 swara Reddy Emani is principal scientist and group leader at Genentech (a 
 member of Roche) since 2020. He did his PhD in biotechnology at the Natio
 nal Center for Cell Sciences (NCCS) at the University of Pune\, India and 
 in 2010\, he joined Professor Riitta Lehesmaa’s laboratory at Turku Bios
 ciences in Turku\, Finland\, as a postdoctoral fellow.\n\n&nbsp\;\n\nAt Ge
 nentech Mahesh leads his team on use of iPSC derived target cells and orga
 noids for in vitro pharmacology. These tools have proved invaluable for id
 entifying promising lead molecules and conducting mechanistic and toxicolo
 gical studies. He is thrilled to be part of an environment committed to co
 nducting science at the highest level and transforming these scientific di
 scoveries into therapeutic solutions that can significantly benefit patien
 ts.\n\n&nbsp\;\n\nSelected publications\n\nSubramanian\, A*.\, Sidhom\, E*
 .\, Maheswarareddy Emani*. et al.Single cell census of human kidney organ
 oids shows reproducibility and diminished off-target cells after transplan
 tation. Nat Commun 10\, 5462 (2019) doi:10.1038/s41467-019-13382-0. * E
 qual Contribution.\n\nMoran Dvela-Levitt\, Maria Kost-Alimova\, Maheswarar
 eddy Emani\, …\, Todd R. Golub\, Eric S. Lander\, Anna Greka. Small mole
 cule targets TMED9 and promotes lysosomal degradation to reverse proteinop
 athy. 2019.\n\nMaheswarareddy Emani\, Närvä E\, …\, Lahesmaa R. The 
 L1TD1 protein interactome reveals the importance of post-transcriptional
  regulation in human pluripotency. Stem Cell Reports. 2015 Mar 10\;4(3
 ):519-28.\n\nNärvä E*\, Rahkonen N*\, Maheswarareddy Emani*\, …\, Lahe
 smaa R. RNA-binding proteinL1TD1 interacts with LIN28 via RNA and is requ
 ired for human embryonic stem cell self-renewal and cancer cell proliferat
 ion. Stem Cells. Stem Cells. 2012 Mar\;30(3):452-60. * These authors contr
 ibuted equally to this article.
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CATEGORIES:Other events
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