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UID:323@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20181009T121500
DTEND;TZID=Europe/Helsinki:20181009T131500
DTSTAMP:20231013T061928Z
URL:https://biocityturku.fi/events/lifespan-seminar-studies-of-post-transl
 ational-modifications-by-mass-spectrometry-reveal-histone-proteoform-dynam
 ics/
SUMMARY:Lifespan seminar: Studies of post-translational modifications by ma
 ss spectrometry reveal histone proteoform dynamics
DESCRIPTION:Lifespan Research Program Seminar\n\nProf. Ole N. Jensen\, Dept
 . Biochemistry &amp\; Molecular Biology\, University of Southern Denmark\,
  Odense\, DK\nStudies of post-translational modifications by mass spectrom
 etry reveal histone proteoform dynamics\n\nHost: Riitta Lahesmaa ( rilahes
 @utu.fi )\n\nCoffee and cookies served at 12:00\n\nProf. Ole N. Jensen obt
 ained the degree of PhD in Biochemistry and Biophysics in 1994 at Oregon S
 tate University at Corvallis\, USA\, based on studies of protein-nucleic a
 cid interactions with professor Douglas F. Barofsky. He then joined the re
 search group of Matthias Mann at the European Molecular Biology Laboratory
  (EMBL) in Heidelberg\, Germany\, where he contributed to the development 
 of mass spectrometry tools for the emerging research field of proteomics.\
 n\nIn 1997 he returned to Odense and the University of Southern Denmark as
  an assistant professor and he initiated studies of protein phosphorylatio
 n using affinity enrichment methods and tandem mass spectrometry. He becam
 e an associate professor in 2000 and then a Lundbeck Foundation Research P
 rofessor 2004-2009. He was awarded an EliteForsk prize from the Danish Min
 istry of Science in 2009 for his contributions to the development of the f
 ield of phosphoproteomics to study cell signaling and regulatory networks.
 \n\nIn recent years\, Ole N. Jensen’s research focus has moved to chroma
 tin biology and epigenetics and “middle-down” proteomics approaches an
 d mass spectrometry to study co-existing post-translational modifications 
 and their cross-talk in proteins. Ole N. Jensen is director of the VILLUM 
 Center for Bioanalytical Sciences at SDU\, which was inaugurated in 2014 b
 ased on a DKK 60M grant from the VILLUM Foundation.  He is also directing
  PRO-MS\, the national Danish research infrastructure for mass spectrometr
 y and functional proteomics.\n\nSelected publications\nAccumulation of his
 tone variant H3.3 with age is associated with profound changes in the hist
 one methylation landscape.\n\nTvardovskiy A\, Schwämmle V\, Kempf SJ\, Ro
 gowska-Wrzesinska A\, Jensen ON. Nucleic Acids Res. 2017 Sep 19\;45(16):92
 72-9289. doi: 10.1093/nar/gkx696. PMID: 28934504\n\nMaximizing Sequence Co
 verage in Top-Down Proteomics By Automated Multi-modal Gas-phase Protein F
 ragmentation. Shliaha PV\, Gibb S\, Gorshkov V\, Jespersen MS\, Andersen G
 R\, Bailey D\, Schwartz J\, Eliuk S\, Schwämmle V\, Jensen ON. Anal Chem.
  2018 Sep 25. doi: 10.1021/acs.analchem.8b02344. [Epub ahead of print] PMI
 D: 30252444\n\nSystems Level Analysis of Histone H3 Post-translational Mod
 ifications (PTMs) Reveals Features of PTM Crosstalk in Chromatin Regulatio
 n. Schwämmle V\, Sidoli S\, Ruminowicz C\, Wu X\, Lee CF\, Helin K\, Jen
 sen ON. Mol Cell Proteomics. 2016 Aug\;15(8):2715-29. doi: 10.1074/mcp.M11
 5.054460. Epub 2016 Jun 14. PMID: 27302890
CATEGORIES:BiocityTurku events
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