BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN BEGIN:VEVENT UID:324@biocityturku.fi DTSTART;TZID=Europe/Helsinki:20180920T130000 DTEND;TZID=Europe/Helsinki:20180920T150000 DTSTAMP:20231013T061928Z URL:https://biocityturku.fi/events/lifespan-seminar-prof-wayne-d-tilley-an d-dr-theresa-e-hickey/ SUMMARY:Lifespan Seminar: Prof. Wayne D. Tilley and Dr. Theresa E. Hickey DESCRIPTION:Prof. Wayne D. Tilley (Adelaide Medical School\, Adelaide\, Aus tralia)\nTowards improved treatment of breast and prostate cancer: novel s trategies to target sex hormone receptors”\n\nDr. Theresa E. Hickey (Ade laide Medical School\, Adelaide\, Australia)\nThe Pas de Deux of Androgen and Estrogen Receptors in Breast Development and Cancer\n\nHost: Prof. Pir kko Härkönen (contact: 040-7343520)\n\n \;\n\nCoffee/tea and cookies at 13:00\n\n \n\nResearch profiles of prof. WD Tilley and Dr. TE Hickey\ n\nProfessor Wayne D Tilley is the Director of the Dame Roma Mitchell Canc er Res Lab\, Adelaide Medical School\, Adelaide\, Australia. His research area has covered widely hormonal carcinogenesis\, mechanisms of steroid ho rmone actions and response and resistance to hormonal treatments. He has p articularly focused on the structure\, mechanisms and functions of androge n receptor starting from cloning of the gene. Recently he has worked on th e splice variants of androgen receptor and in their role in the developmen t of castration resistant prostate cancer. He has also been involved in de velopment of novel ligands for androgen receptor\, aimed at treatment of c astration resistant prostate cancer and other indications. Prof. Tilley’ s research has led to several original findings and concepts\, published a t highly ranked journals.\n\n \;\n\nA detailed description of Prof Til ley’s research career and present projects can be found at: https://rese archers.adelaide.edu.au/profile/wayne.tilley\n\nDr Theresa E. Hickey is a Senior Research Fellow and Head of the Breast Cancer Research Laboratory a t the Dame Rome Mitchell Cancer Research Laboratories (DRMCRL)\, School of Medicine\, University of Adelaide. She has previously worked on reproduct ive medicine and specifically\, on androgen receptor (AR) signaling in hum an ovarian tissues and in polycystic ovary syndrome (PCOS). Her current re search focuses on AR signaling in human breast biology and breast cancer a nd its potential exploitation in development of breast cancer therapies.  Her ongoing collaboration with Prof Carroll’s laboratory in Cambridge h as resulted in a recent Nature paper (2015)\, and co-authorship of a paper in Nature Genetics (2016) with another Cambridge colleague\, Dr. Kerstin Meyer\, both of which received extensive media coverage both nationally an d internationally.\n\nA more detailed description of Dr Hickey´s research career is found at: https://researchers.adelaide.edu.au/profile/theresa.h ickey\n\nSelected recent publications of Prof. WD Tilley and Dr. TE Hickey \n\nCentenera MM\, Hickey TE\, Jindal S\, Ryan NK\, Ravindranathan P\, Moh ammed H\, Robinson JL\, Schiewer MJ\, Ma S\, Kapur P\, Sutherland PD\, Hof fmann CE\, Roehrborn CG\, Gomella LG\, Carroll JS\, Birrell SN\, Knudsen K E\, Raj GV\, Butler LM\, Tilley WD. A patient-derived explant (PDE) model of hormone-dependent cancer. Mol Oncol. 2018 Aug 16. doi: 10.1002/1878-026 1.12354. [Epub ahead of print]\n\nRicciardelli C\, Bianco-Miotto T\, Jinda l S\, Butler LM\, Leung S\, McNeil CM\, O'Toole SA\, Ebrahimie E\, Millar EKA\, Sakko AJ\, Ruiz AI\, Vowler SL\, Huntsman DG\, Birrell SN\, Sutherla nd RL\, Palmieri C\, Hickey TE\, Tilley WD. The Magnitude of Androgen Rece ptor Positivity in Breast Cancer Is Critical for Reliable Prediction of Di sease Outcome. Clin Cancer Res. 2018 May 15\;24(10):2328-2341.\n\nTarulli GA\, Laven-Law G\, Shehata M\, Walters KA\, Denis IM\, Rahman MM\, Handels man DJ\, Dean NR\, Tilley WD\, Hickey TE. Androgen Receptor Signalling Pro motes a Luminal Phenotype in Mammary Epithelial Cells. J Mammary Gland Bio l Neoplasia. 2018 Aug 12. doi: 10.1007/s10911-018-9406-2. [Epub ahead of p rint]\n\nCarroll JS\, Hickey TE\, Tarulli GA\, Williams M\, Tilley WD. Dec iphering the divergent roles of progestogens in breast cancer. Nat Rev Can cer. 2017 Jan\;17(1):54-64. doi: 10.1038/nrc.2016.116. Review.\n\nPonnusam y S\, Coss CC\, Thiyagarajan T\, Watts K\, Hwang DJ\, He Y\, Selth LA\, Mc Ewan IJ\, Duke CB\, Pagadala J\, Singh G\, Wake RW\, Ledbetter C\, Tilley WD\, Moldoveanu T\, Dalton JT\, Miller DD\, Narayanan R. Novel Selective A gents for the Degradation of Androgen Receptor Variants to Treat Castratio n-Resistant Prostate Cancer. Cancer Res. 2017 Nov 15\;77(22):6282-6298.\n\ nPaltoglou S\, Das R\, Townley SL\, Hickey TE\, Tarulli GA\, Coutinho I\, Fernandes R\, Hanson AR\, Denis I\, Carroll JS\, Dehm SM\, Raj GV\, Plymat e SR\, Tilley WD\, Selth LA. Novel Androgen Receptor Coregulator GRHL2 Exe rts Both Oncogenic and Antimetastatic Functions in Prostate Cancer. Cancer Res. 2017 Jul 1\;77(13):3417-3430.\n\nDas R\, Gregory PA\, Fernandes RC\, Denis I\, Wang Q\, Townley SL\, Zhao SG\, Hanson AR\, Pickering MA\, Arms trong HK\, Lokman NA\, Ebrahimie E\, Davicioni E\, Jenkins RB\, Karnes RJ\ , Ross AE\, Den RB\, Klein EA\, Chi KN\, Ramshaw HS\, Williams ED\, Zoubei di A\, Goodall GJ\, Feng FY\, Butler LM\, Tilley WD\, Selth LA. MicroRNA-1 94 Promotes Prostate Cancer Metastasis by Inhibiting SOCS2. Cancer Res. 20 17 Feb 15\;77(4):1021-1034.\n\nHu DG\, Selth LA\, Tarulli GA\, Meech R\, W ijayakumara D\, Chanawong A\, Russell R\, Caldas C\, Robinson JL\, Carroll JS\, Tilley WD\, Mackenzie PI\, Hickey TE. Androgen and Estrogen Receptor s in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17. Cancer Res. 2016 Oct 1\;76(19):5881-5893.\n\nSelth LA\, Das R\, Town ley SL\, Coutinho I\, Hanson AR\, Centenera MM\, Stylianou N\, Sweeney K\, Soekmadji C\, Jovanovic L\, Nelson CC\, Zoubeidi A\, Butler LM\, Goodall GJ\, Hollier BG\, Gregory PA\, Tilley WD. A ZEB1-miR-375-YAP1 pathway regu lates epithelial plasticity in prostate cancer. Oncogene. 2017 Jan 5\;36(1 ):24-34. doi: 10.1038/onc.2016.185.\n\nCastro MA\, de Santiago I\, Campbel l TM\, Vaughn C\, Hickey TE\, Ross E\, Tilley WD\, Markowetz F\, Ponder BA \, Meyer KB. Regulators of genetic risk of breast cancer identified by int egrative network analysis. Nat Genet. 2016 Jan\;48(1):12-21\n\nTarulli GA\ , Laven-Law G\, Shakya R\, Tilley WD\, Hickey TE. Hormone-sensing mammary epithelial progenitors: emerging identity and hormonal regulation. J Mamma ry Gland Biol Neoplasia. 2015\;20:75-91.\n\nMohammed H\, Russell IA\, Star k R\, Rueda OM\, Hickey TE\, Tarulli GA\, Serandour AA\, Birrell SN\, Brun a A\, Saadi A\, Menon S\, Hadfield J\, Pugh M\, Raj GV\, Brown GD\, D'Sant os C\, Robinson JL\, Silva G\, Launchbury R\, Perou CM\, Stingl J\, Caldas C\, Tilley WD\, Carroll JS. Progesterone receptor modulates ERα action i n breast cancer. Nature. 2015 Jul 16\;523(7560):313-7. CATEGORIES:BiocityTurku events LOCATION:#_LOCATIONNAME\, #_LOCATIONFULLLINE\, #_LOCATIONCOUNTRY X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=#_LOCATIONFULLLINE\, #_LOCA TIONCOUNTRY;X-APPLE-RADIUS=100;X-TITLE=#_LOCATIONNAME:geo:0,0 END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20180325T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR