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UID:327@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20181204T130000
DTEND;TZID=Europe/Helsinki:20181204T140000
DTSTAMP:20231013T062129Z
URL:https://biocityturku.fi/events/lifespan-seminar-gpcr-mediated-biologic
 al-effects-of-hydroxylated-arachidonic-acid-hete-metabolites/
SUMMARY:Lifespan seminar: GPCR-mediated biological effects of hydroxylated 
 arachidonic acid (HETE) metabolites
DESCRIPTION:Dr. Sorin Tunaru\, Max-Planck-Institute for Heart and Lung Rese
 arch\, Bad Nauheim\, Germany\n\nGPCR-mediated biological effects of hydrox
 ylated arachidonic acid (HETE) metabolites\n\n&nbsp\;\n\nCoffee and cookie
 s at 11.45\n\nHost: Jukka Kero (jukka.kero@utu.fi)\n\nSorin Tunaru obtaine
 d his PhD in molecular pharmacology at the University of Heidelberg\, Germ
 any. His research was devoted to understanding the contribution of G-prote
 in coupled receptors (GPCRs) in physiology and pathology. In 2009 he was r
 ecruited to Max Planck Institute for Heart and Lung Research (Bad Nauheim\
 , Germany) to expand the research on the identification of receptors for n
 ovel lipid metabolites.\n\nSince 2018\, he is working at the Romanian Acad
 emy of Sciences\, Institute of Biochemistry where he is building his own m
 olecular pharmacology research team. The aims of his research is to unders
 tand the biological roles of GPCRs for which no endogenous ligands have be
 en so far discovered\, termed orphan GPCRs (oGPCRs).\n\nSelected Publicati
 ons\n\nTunaru S\, Bonnavion R\, Brandenburger I\, Preussner J\, Thomas D\,
  Scholich K\, Offermanns S. 20-HETE promotes glucose-stimulated insulin se
 cretion in an autocrine manner through FFAR1 (GPR40). Nat Commun. 2018 Jan
  12\; 9(1):177.\n\nTunaru S Strategies for G-protein coupled receptor deor
 phanization. Mol Life\, 2017\, Vol 1\, No. 1\, 71-79. doi: 10.26600/MolLif
 e.1.1.8.2017\n\nTunaru S\, Chennupati R\, Nüsing RM\, Offermanns S.Arachi
 donic acid metabolite 19(S)-HETE induces vasorelaxation and platelet inhib
 ition byactivating prostacyclin (IP) receptor. PLoS One 2016 Sep 23\; 11(9
 )\n\nTang C\, Ahmed K\, Gille A\, Lu S\, Gröne HJ\, Tunaru S\, Offermanns
  S. Loss of FFA2 and FFA3 increases insulin secretion and improves glucose
  tolerance in type 2 diabetes. Nat Med. 2015 Feb\; 21(2):173-7. doi: 10.10
 38/nm.3779.\n\nTunaru S\, Althoff TF\, Nüsing RM\, Diener M\, Offermanns 
 S. Castor oil induces laxation and uterus contraction via ricinoleic acid 
 activating prostaglandin EP3 receptors. Proc Natl Acad Sci U S A. 2012 Jun
  5\; 109(23):9179-84\n\nTunaru S\, Kero J\, Schaub A\, Wufka C\, Blaukat A
 \, Pfeffer K\, Offermanns S.PUMA-G and HM74 are receptors for nicotinic ac
 id and mediate its anti-lipolytic effect. Nat Med. 2003 Mar\; 9(3):352-5.
CATEGORIES:BiocityTurku events
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BEGIN:VTIMEZONE
TZID:Europe/Helsinki
X-LIC-LOCATION:Europe/Helsinki
BEGIN:STANDARD
DTSTART:20181028T030000
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