BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN BEGIN:VEVENT UID:215@biocityturku.fi DTSTART;TZID=Europe/Helsinki:20181115T123000 DTEND;TZID=Europe/Helsinki:20181115T143000 DTSTAMP:20231013T061300Z URL:https://biocityturku.fi/events/special-seminar-serini-and-miserey-link ei/ SUMMARY:Special seminar: Serini and Miserey-Linkei DESCRIPTION:Coffee/tea and snack available before the talks\n\nThe two spea kers:\n\n Guido Serini (University of Torino Medical School)\n\n\n Title of talk: "Mechanisms of β1 integrin activation and clustering in the con trol of endothelial cell adhesion and migration". This will be unpublished data.\n If time allows\, Prof Serini will also summarise some recent wor k on semaphorin\, its co-receptor neuropilin 1 and new binding partners an d the implications of these novel interactions in vascular morphogenesis a nd function.\n\nIn his earlier work\, Prof Serini showed for the first tim e how endothelial class 3 semaphorins (SEMA3) signal through plexin recept ors to inhibit integrins and allow vascular morphogenesis (Serini et al.\, Nature 2003). More recently\, his research group rationally designed\, ge nerated and characterized a mutant\, protease resistant\, and easily purif iable superagonist SEMA3A protein isoform that represents a parenterally-d eliverable drug that effectively normalizes the cancer vasculature (Gioell i et al.\, Sci. Transl. Med. 2018). His lab has also unveiled how vascular morphogenesis relies not only on integrin conformational activation\, but also on dedicated signalling pathways that control the endocytosis and re cycling of conformationally active integrins to adhesion sites in coordina tion with TGN-dependent polarized fibronectin secretion (Valdembri et al.\ , PloS Biol. 2009\; Sandri et al.\, Cell Res. 2012\; Mana et al.\, Nat. Co mmun. 2016).\n\nProf. Serini will serve as Pranshu Sahgal’s PhD opponent on Friday 16th November!\n\nSelected publications (Guido Serini):\n\n                 Semaphorins and angiogenesis \n\n G. Serini*\, V. Valdembri\, S. Zanivan\, G. Morterra\, C. Burkhardt\, F. Caccavari\, L . Zammataro\, L. Primo\, L. Tamagnone\, M. Logan\, M. Tessier-Lavigne\, M. Taniguchi\, A.W. Püschel\, and F. Bussolino*. Class 3 semaphorins contro l vascular morphogenesis by inhibiting integrin function. Nature 2003\, 42 4: 391-397. *Shared corresponding authorship. \n F. Maione\, F. Molla\, C . Meda\, R. Latini\, L. Zentilin\, M. Giacca\, G. Seano\, G. Serini*\, F. Bussolino*\, and E. Giraudo*. Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in tra nsgenic mouse models. J. Clin. Invest. 2009\, 119: 3356-3372. *Shared seni or authorship. \n N. Gioelli\, F. Maione\, C. Camillo\, M. Ghitti\, D. Va ldembri\, N. Morello\, M. Darche\, L. Zentilin\, G. Cagnoni\, Y. Qiu\, M. Giacca\, M. Giustetto\, M. Paques\, I. Cascone\, G. Musco\, L. Tamagnone\, E. Giraudo\, and G. Serini. A rationally designed NRP1-independent supera gonist SEMA3A mutant is an effective anticancer agent. Sci. Transl. Med. 2 018\, 10: eaah4807.\n\n                Active integrin traf fic \n\n D. Valdembri\, P.T. Caswell\, K.I. Anderson\, J.P. Schwarz\, I. König\, E. Astanina\, F. Caccavari\, J.C. Norman\, M.J. Humphries\, F. Bu ssolino\, and G. Serini. Neuropilin−1/GIPC1 Signaling Regulates α5β1 I ntegrin Traffic and Function in Endothelial Cells. PLoS Biology 2009\, 7:e 1000025.\n C. Sandri\, F. Caccavari\, D. Valdembri\, C. Camillo\, S. Velt el\, M. Santambrogio\, L. Lanzetti\, F. Bussolino\, J. Ivaska\, and G. Ser ini. The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and mo rphogenesis via active integrin endocytosis and Rac signaling. Cell Res. 2 012\, 22:1479-1501.\n G. Mana\, F. Clapero\, E. Panieri\, V. Panero\, R. T. Böttcher\, H.Y. Tseng\, F. Saltarin\, E. Astanina\, K.I. Wolanska\, M. R. Morgan\, M.J. Humphries\, M.M. Santoro\, G. Serini*\, and D. Valdembri *. PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis. Nat. Commun. 2016\, 7: 13546. *Shared senior and corresponding authorship.\n\n \;\n\n Stephanie Mi serey-Linkei (Institut Curie\, PSL Research University)\n\n\n Title of ta lk: “Getting out the Golgi complex thanks to the RAB6 GTPase”\n\nDr Mi serey-Linkei is a talented senior researcher in the group of Prof. Bruno G oud in Institut Curie. She investigates the mechanisms regulating cellular transport with a focus on unravelling the role of Rab GTPases\, the Golgi network and microtubules in this important biological process.\n\nSelecte d publications (Stephanie Miserey-Linkei):\n\n Miserey-Lenkei S\, Bousque t H\, Pylypenko O\, Bardin S\, Dimitrov A\, Bressanelli\, G\, Bonifay R\, Fraisier V\, Guillou C\, Bougeret C\, Houdusse A\, Echard A\, Goud B. Coup ling fission and exit of RAB6 vesicles at Golgi hotspots through kinesin-m yosin interactions. Nat Commun. 2017\, 8(1):1254.\n Patwardhan A\, Bardin S\, Miserey-Lenkei S\, Larue L\, Goud B\, Raposo G\, Delevoye C. Routing of the RAB6 secretory pathway towards the lysosome related organelle of me lanocytes. Nat Commun. 2017\, 8:15835.\n Miserey-Lenkei S\, Colombo MI. S mall RAB GTPases Regulate Multiple Steps of Mitosis. Front Cell Dev Biol. 2016\, 4:2. Review.\n Delevoye C\, Miserey-Lenkei S\, Montagnac G\, Gille s-Marsens F\, Paul-Gilloteaux P\, Giordano F\, Waharte F\, Marks MS\, Goud B\, Raposo G. Recycling endosome tubule morphogenesis from sorting endoso mes requires the kinesin motor KIF13A. Cell Rep. 2014\, 6(3):445-54.\n Al Awabdh S\, Miserey-Lenkei S\, Bouceba T\, Masson J\, Kano F\, Marinach-Pa trice C\, Hamon M\, Emerit MB\, Darmon M. A new vesicular scaffolding comp lex mediates the G-protein-coupled 5-HT1A receptor targeting to neuronal d endrites. J Neurosci. 2012\, 32(41):14227-41.\n Miserey-Lenkei S\, Wahart e F\, Boulet A\, Cuif MH\, Tenza D\, El Marjou A\, Raposo G\, Salamero J\, Héliot L\, Goud B\, Monier S. Rab6-interacting protein 1 links Rab6 and Rab11 function. Traffic. 2007\, 8(10):1385-403.\n Miserey-Lenkei S\, Cou ëdel-Courteille A\, Del Nery E\, Bardin S\, Piel M\, Racine V\, Sibarita JB\, Perez F\, Bornens M\, Goud B. A role for the Rab6A' GTPase in the ina ctivation of the Mad2-spindle checkpoint. EMBO J. 2006\, 25(2):278-89.\n CATEGORIES:BiocityTurku events,Other events LOCATION:#_LOCATIONNAME\, #_LOCATIONFULLLINE\, #_LOCATIONCOUNTRY X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=#_LOCATIONFULLLINE\, #_LOCA TIONCOUNTRY;X-APPLE-RADIUS=100;X-TITLE=#_LOCATIONNAME:geo:0,0 END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:STANDARD DTSTART:20181028T030000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:EET END:STANDARD END:VTIMEZONE END:VCALENDAR