BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN BEGIN:VEVENT UID:790@biocityturku.fi DTSTART;TZID=Europe/Helsinki:20250616T140000 DTEND;TZID=Europe/Helsinki:20250616T150000 DTSTAMP:20250606T091806Z URL:https://biocityturku.fi/events/inflames-guest-seminar-2/ SUMMARY:InFLAMES Guest Seminar DESCRIPTION:16th June at 14:00-15:00\nOnsite event\nin Alhopuro Auditorium\ , Medisiina D\n\nProf. Shimon Sakaguchi\, Osaka University\, Japan\nInduct ion of regulatory T cells for immune tolerance\, a synthetic immunology ap proach\n\nHost: Riitta Lahesmaa (rilahes@utu.fi)\n\nShimon Sakaguchi is a Distinguished Professor at the World Premier International Research Initia tive (WPI)-Immunology Frontier Research Center (IFReC) at Osaka University \, Japan. He is an immunologist recognized for his work on the control of immune responses. He is known particularly for his discovery of regulatory T cells\, an indispensable constituent of the immune system for the maint enance of immune self-tolerance and homeostasis. Sakaguchi obtained an M.D . in 1976 and a Ph.D. in 1982 from Kyoto University\, Japan\, where he was trained as a pathologist and immunologist. After performing postdoctoral studies at Johns Hopkins University and Stanford University\, he served as an Assistant Professor in the Department of Immunology at the Scripps Res earch Institute. After returning to Japan he was a Professor and the Chair man of the Department of Experimental Pathology\, Institute for Frontier M edical Sciences Kyoto University and served as the Director of the Institu te for several years. In 2011\, his lab moved to Osaka University and he a ssumed the current position. He has received numerous prestigious internat ional awards. Sakaguchi is the Sigrid Jusélius Foundation Visiting Profes sor at the University of Turku.\n\nSakaguchi studies the molecular and cel lular mechanisms of immunological tolerance and immune regulation. He has shown that a population of immunosuppressive T-lymphocytes\, designated re gulatory T cells\, are present in the immune system and its deficiency or dysfunction is causative of a variety of immunological disorders including autoimmune diseases. He has investigated the molecular basis of regulator y T cell development and function. In addition\, Sakaguchi and his laborat ory have demonstrated that numerical expansion of regulatory T cells or st rengthening of their suppressive activity is capable of preventing and tre ating autoimmune diseases and also establishing stable tolerance to transp lanted organs\, while their reduction in number or suppressive activity is able to provoke effective immunity against cancer. Sakaguchi is currently investigating how regulatory T cells can be targeted in humans to control a variety of physiological and pathological immune responses in clinical settings.\n\n \;\n\nSelected recent publications \n\nOsaki M\, Sakaguc hi S. Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity. Immuni ty. 58(4):889-908.e13\, 2025. doi: 10.1016/j.immuni.2025.03.004.\n\nChen K Y\, Kibayashi T\, Giguelay A\, Hata M\, Nakajima S\, Mikami N\, Takeshima Y\, Ichiyama K\, Omiya R\, Ludwig LS\, Hattori K\, Sakaguchi S. Genome-wid e CRISPR screen in human T cells reveals regulators of FOXP3. Nature. Mar 26\, 2025. doi: 10.1038/s41586-025-08795-5.\n\nIchiyama K\, Long J\, Kobay ashi Y\, Horita Y\, Kinoshita T\, Nakamura Y\, Kominami C\, Georgopoulos K \, Sakaguchi S. Transcription factor Ikzf1 associates with Foxp3 to repres s gene expression in Treg cells and limit autoimmunity and anti-tumor immu nity.  Immunity. 57(9):2043-2060.e10\, 2024. doi: 10.1016/j.immuni.2024.0 7.010. Epub 2024 Aug 6.\n\nTay C\, Tanaka A\, Sakaguchi S. Tumor-infiltrat ing regulatory T cells as targets of cancer immunotherapy.  Cancer Cell. 41(3):450-465\, 2023. doi: 10.1016/j.ccell.2023.02.014.\n\nSakaguchi S. T aking regulatory T cells into medicine.  J Exp Med. 218(6):e20210831\, 20 21. doi: 10.1084/jem.20210831.\n\nKawakami R\, Kitagawa Y\, Chen KY\, Arai M\, Ohara D\, Nakamura Y\, Yasuda K\, Osaki M\, Mikami N\, Lareau CA\, Wa tanabe H\, Kondoh G\, Hirota K\, Ohkura N\, Sakaguchi S. Distinct Foxp3 en hancer elements coordinate development\, maintenance\, and function of reg ulatory T cells.  Immunity. 54(5):947-961.e8\, 2021. doi: 10.1016/j.immu ni.2021.04.005.\n\nSakaguchi S\, Mikami N\, Wing JB\, Tanaka A\, Ichiyama K\, Ohkura N. Regulatory T Cells and Human Disease. Annu Rev Immunol. 38:5 41-566\, 2020. doi: 10.1146/annurev-immunol-042718-041717. ATTACH;FMTTYPE=image/jpeg:https://biocityturku.fi/wp-content/uploads/Infla mesGuestSeminar3_.jpg CATEGORIES:Other events END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20250330T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR