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UID:745@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20250304T140000
DTEND;TZID=Europe/Helsinki:20250304T150000
DTSTAMP:20250304T083236Z
URL:https://biocityturku.fi/events/immunology-seminar-hetemaki/
SUMMARY:Immunology Seminar\, Hetemäki
DESCRIPTION:4th March at 14:00-15:00\nOnline event\nin Zoom\nFlyer\n\nDr. 
  Iivo Hetemäki\, National Institute of Allergy and Infectious Diseases\,
  USA\nImmune dysregulation in patients with IKZF2 (Helios) deficiency\n\nH
 ost: Professor Riitta Lahesmaa (rilahes@utu.fi)\n\nLink to the online semi
 nar: https://utu.zoom.us/j/62786995489\n\nImmunology seminar series is joi
 ntly organised by the Finnish Society for Immunology\, InFLAMES Flagship a
 nd Turku Bioscience. For further information contact Anne Lahdenperä  (a
 nkahy@utu.fi) or Riitta Lahesmaa (rilahes@utu.fi)\, University of Turku.\n
 \n \n\nIivo Hetemäki is a physician-scientist with long interest in lymp
 hocyte biology especially in inborn errors of immunity (IEI). He did his P
 hD thesis “Regulation of the Germinal Centre Reaction in Inborn Errors o
 f Immunity” under the supervision of Petteri Arstila and Eliisa Kekälä
 inen in Helsinki University. In his thesis he examined regulation of adapt
 ive immune responses and factors underlying rise of neutralizing anti-inte
 rferon antibodies in two inborn error of immunity AIRE deficiency Autoimmu
 ne Polyendocrinopathy Candidiasis Ectodermal Dystropyhy (APECED) and IKZF2
  (encoding for Helios) loss of function mutation. The report by Hetemäki 
 &amp\; al. was first IKZF2 deficiency described in men. For his thesis Het
 emäki received the PhD thesis award from Immunology by Finnish Society of
  Immunology. Currently\, Hetemäki is continuing postdoctoral research at 
 the National Institutes of Health under the supervision of Mihalis Lionaki
 s. He has also worked as physician treating patients with IEI.\n\n&nbsp\;\
 n\nSelected publications\n\nHetemäki I\, Kaustio M\, Kinnunen M\, Heikkil
 ä N…\, Kekäläinen E. Loss-of-function mutation in IKZF2 leads to im
 munodeficiency with dysregulated germinal center reactions and reduction o
 f MAIT cells. Sci Immunol. 2021 26\;6(65)\n\nHetemäki I\, Arstila TP\, Ke
 käläinen E. Helios-Illuminating the way for lymphocyte self-control. Imm
 unology. 2024\n\nHetemäki I\, Sarkkinen J\, Heikkilä N\, &amp\; al. Dysr
 egulated germinal centre reaction with expanded T follicular helper cells 
 in APECED lymph nodes. J Allergy Clin Immunol. 2023\n\nHetemäki\, I.\, La
 akso\, S.\, Välimaa\, H.\, Kleino\, I.\, Kekäläinen\, E.\, Mäkitie\, O
 .\, Arstitila\, TP. Patients with autoimmune polyendocrine syndrome type 1
  have an increased susceptibility to severe herpesvirus infections. Clin I
 mmunol. 2021
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 aki.jpg
CATEGORIES:Other events
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TZID:Europe/Helsinki
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DTSTART:20241027T030000
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