BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN BEGIN:VEVENT UID:615@biocityturku.fi DTSTART;TZID=Europe/Helsinki:20240507T140000 DTEND;TZID=Europe/Helsinki:20240507T150000 DTSTAMP:20240506T060515Z URL:https://biocityturku.fi/events/immunology-seminar-2/ SUMMARY:Immunology Seminar DESCRIPTION:May 7th at 14:00\nOnline event\nin Zoom\nFlyer\n\nKatri Lindfor s\, Celiac Disease Research Center\, Faculty of Medicine and Health Techno logy\, Tampere University: Phenotypic spectrum of celiac disease – a que st for underlying mechanisms\n\nHost: Riitta Lahesmaa (rilahes@utu.fi)\n\n Join the Zoom https://utu.zoom.us/j/67738007310\n\nImmunology seminar seri es is jointly organised by the Finnish Society for Immunology\, InFLAMES F lagship and Turku Bioscience. For further information contact Anne Lahdenp erä  (ankahy@utu.fi) or Riitta Lahesmaa (rilahes@utu.fi)\, University of Turku.\n\n \;\n\nKatri Lindfors is a professor of molecular biology a nd the vice director of Celiac Disease Research Center at Tampere Universi ty. She is a member of the organizing committee of the Tampere Celiac Dise ase Symposium\, the scientific advisory board of the patient organization Finnish Celiac Society and International Society for the Study of Celiac D isease.\n\nShe has conducted translational celiac disease research over 20 years and published over 100 peer-reviewed articles. Her previous work ha s contributed to the understanding of factors involved in celiac disease p athogenesis including the potential role of enteroviruses as a triggering factor and the biological functions of celiac disease specific autoantibod ies targeting a self-protein transglutaminase 2 (TG2).  Currently her gro up focuses on identifying factors contributing to the heterogenous clinica l picture of celiac disease using dermatitis herpetiformis\, the skin mani festation of celiac disease\, as a model phenotype. Up to now\, her result s indicate that in addition to a distinct genetic predisposition\, an auto immune response against a TG3\, a homologue of celiac disease autoantigen TG2 is implicated in dermatitis herpetiformis. Ongoing studies are address ing the questions whether dermatitis herpetiformis pathogenesis is initiat ed in the small bowel mucosa and how the disease spreads from gut to skin as a consequence of unrecognized and untreated celiac disease.\n\n \;\ n\nSelected publications\n\nDas S\, Stamnaes J\, Kemppainen E\, Hervonen K \, Lundin KEA\, Parmar N\, Jahnsen FL\, Jahnsen J\, Lindfors K\, Salmi T\, Iversen R\, Sollid LM. Separate Gut Plasma Cell Populations Produce Auto- Antibodies against Transglutaminase 2 and Transglutaminase 3 in Dermatitis Herpetiformis. Adv Sci (Weinh) 2023\;10:e2300401.  doi: 10.1002/advs.202 300401.\n\nKalliokoski S\, Mansikka E\, de Kauwe A\, Huhtala H\, Saavalain en P\, Kurppa K\, Hervonen K\, Reunala T\, Kaukinen K\, Salmi T\, Lindfors K. Gliadin-induced ex vivo T cell response in dermatitis herpetiformis: A predictor of clinical relapse on gluten challenge? J Invest Dermatol\, 20 20\;140:1867-1869.e2 doi: 10.1016/j.jid.2019.12.038.\n\nLindfors K\, Ciacc i C\, Kurppa K\, Lundin K\, Makharia G\, Mearin ML\, Murray J\, Verdu E\, Kaukinen K. Coeliac Disease. Nature Reviews Disease Primers 2019\;5:3 DOI: 10.1038/s41572-018-0054-z.\n\nHietikko M\, Hervonen K\, Salmi T\, Ilus T\, Zone JJ\, Kaukinen K\, Reunala T\, Lindfors K. Disappearance of epidermal transglutaminase and IgA deposits from the papillary dermis of dermatitis herpetiformis patients after a long-term gluten-free diet. Brit J Dermato l 2018\;178:e198-e201. doi: 10.1111/bjd.15995. ATTACH;FMTTYPE=image/jpeg:https://biocityturku.fi/wp-content/uploads/katri -arvossa_pieni.jpg END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20240331T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR