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UID:620@biocityturku.fi
DTSTART;TZID=Europe/Helsinki:20240515T101500
DTEND;TZID=Europe/Helsinki:20240515T120000
DTSTAMP:20240513T082234Z
URL:https://biocityturku.fi/events/human-diversity-seminar/
SUMMARY:Human Diversity Seminar
DESCRIPTION:15th May at 10:15-12:00\nHybrid event\nin Agora building\, hall
  XXI and https://utu.zoom.us/j/61515345616\n\nProf. Juha Kere\, Department
  of Biosciences and Nutrition\, Karolinska Institutet\, Sweden\nGenes\, en
 vironment and chance\n\nDr. Elina Salmela\, Department of Biology\, Univer
 sity of Turku\; Max Planck Institute for Evolutionary Anthropology\, Leipz
 ig\nThe skull of a saint? A genetic analysis of the purported cranium of S
 t. Henry from the Cathedral of Turku\n\nHuman Diversity (Profi7 consortium
  at UTU) arranges interdisciplinary seminar series to present the wide var
 iety of research in the field\, highlighting interdisciplinary research as
 sociated with the consortium. The topics include human population genomics
 \, ancient DNA\, ancient pathogens and diseases as well as life history tr
 aits in humans\, archeology and linguistics.\n\n&nbsp\;\n\nGet to know the
  topics\n\nJuha Kere\nIn genetics\, we often think of gene effects as rath
 er deterministic\, as illustrated by monogenic inheritance and diseases. H
 owever\, besides the genes and environmental effects\, chance is the third
  major factor in multiple aspects of our lives\, including even developmen
 tal processes. I will discuss major aspects of genetic research findings a
 nd applications\, including our improved understanding of the genetic arch
 itecture of complex disorders and of gene regulation\, a new approach for 
 drug discovery\, and the low utility of polygenic risk scores (PRS) as pre
 dictors of common\, complex disorders such as coronary artery disease. As 
 alternative approaches for personalized medicine\, I will briefly highligh
 t new methods based on proteomics\, metabolomics\, cell-free-DNA (cfDNA)\,
  and imaging technologies as dynamic markers of health.\n\nElina Salmela\n
 In 1924\, a human skull was found carefully hidden in a wall niche in the 
 main cathedral of Turku. The skull's origin (i.e.\, provenance) is unknown
 \, but some claim it to have belonged to St. Henry\, the patron saint of n
 ow-Lutheran Finland\, whose historicity\, however\, is unclear. The skull 
 has been radiocarbon dated to the 11th-12th century CE\, in congruence wit
 h the legend of St. Henry\, which portrays him as a bishop of Uppsala who 
 arrived in Finland in the 1150s to baptize the natives and got murdered by
  a local peasant. We have sampled the skull for ancient-DNA sequencing\, a
 nd I will present results of analyses attempting to pinpoint the individua
 l's genetic history on the map.
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CATEGORIES:Other events
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