BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.4.5//EN BEGIN:VEVENT UID:960@biocityturku.fi DTSTART;TZID=Europe/Helsinki:20260925T090000 DTEND;TZID=Europe/Helsinki:20260925T103000 DTSTAMP:20260922T144134Z URL:https://biocityturku.fi/events/guest-seminar/ SUMMARY:Guest Seminar DESCRIPTION:Guest Seminar\n\n25th September at 09:00-10:30\nOnsite event\ni n Den2\, Dentalia 2nd floor\n\nAssoc. Prof. Frank J. Hernandez\, Linköpin g University\, Sweden\nProgramming biology with nucleic acids: From molecu lar diagnostics to targeted therapeutics\n\nProf. Vicente Pelechano Garcia \, Karolinska Institutet\, Sweden\nGenomic dissection of mRNA decay: from mechanism to clinical applications\n\n \n\nDr. Frank J. Hernandez is a Se nior Associate Professor at Linköping University and at the University of Navarra. His research focuses on the development of nucleic-acid-based te chnologies at the interface of molecular diagnostics\, precision therapeut ics\, and drug delivery. His group has developed programmable oligonucleot ide systems for sensing disease-associated enzymatic activity and for the targeted activation and delivery of therapeutics. His current research exp lores how engineered nucleic-acid substrates can be combined to create pr ogrammable therapeutic systems for infectious diseases and cancer.\n\nSele cted publications\n\n Hernandez FJ\, Huang L\, Olson ME\, et al. Noninva sive imaging of Staphylococcus aureusinfections with a nuclease-activated probe.  Med. 2014\;20:301–306. DOI:10.1038/nm.3460.\n Borsa BA\, Hern andez LI\, Jiménez T\, et al. Therapeutic-oligonucleotides activated by nucleases (TOUCAN): A nanocarrier system for the specific delivery of clin ical nucleoside analogues.  Control. Release. 2023\;361:260–269. DOI:10 .1016/j.jconrel.2023.07.057.\n Hernandez FJ. Nucleases: From Primitive I mmune Defenders to Modern Biotechnology Tools. Immunology. 2025\;174:279 –286. DOI:10.1111/imm.13884.\n\n \;\n\nDr. Vicent Pelechano is a Pro fessor of RNA Biology at Karolinska Institutet. His is an expert in the fi eld of genome-wide approaches\, particularly in eukaryotic transcription a nd transcriptome complexity. From the beginning of his scientific career\, he has successfully combined experimental and computational work aiming t o develop and apply novel genome-wide techniques to address fundamental bi ological questions with medical implications. His group is currently conce ntration on understanding molecular bases of non-genetic cellular heteroge neity\, crosstalk between ribosome dynamics and mRNA degradation\, and dev elopment of novel tools for molecular diagnosis.\n\nSelected publications\ n\n Zhang Y\, Nersisyan L\, Fürst E\, et al. Ribosomes modulate transcri ptome abundance via generalized frameshift and out-of-frame mRNA decay. Mo l Cell. 2025\;85:2017–2031.e7. DOI: 10.1016/j.molcel.2025.04.022.\n Tay yab M\, Barrett D\, van Riel G\, et al. Digital assay for rapid electronic quantification of clinical pathogens using DNA nanoballs. Adv. 2023\;9:e adi4997. DOI: 10.1126/sciadv.adi4997.\n Huch S\, Nersisyan L\, Ropat M\, et al. Atlas of mRNA translation and decay for bacteria. Microbiol. 2023\ ;8:1123–1136. DOI: 10.1038/s41564-023-01393-z.\n ATTACH;FMTTYPE=image/jpeg:https://biocityturku.fi/wp-content/uploads/UTU-t humbnail-vihrea.jpg CATEGORIES:Other events END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20260329T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR