BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN BEGIN:VEVENT UID:542@biocityturku.fi DTSTART;TZID=Europe/Helsinki:20240418T120000 DTEND;TZID=Europe/Helsinki:20240418T130000 DTSTAMP:20231220T164708Z URL:https://biocityturku.fi/events/frontiers-of-science-prof-saverio-minuc ci/ SUMMARY:Frontiers of Science: Prof. Saverio Minucci DESCRIPTION:April 18th at 12:00\nOn-site event\nPresidentti auditorium\, Bi oCity\nSpring 2024 program\n\nProf. Saverio Minucci\, Istituto Europeo di Oncologia\, Italy\nPP2A as an integrator of cellular responses to genomic stress\, and to a metabolically dynamic microenvironment\nHost: Jukka West ermarck (jukwes@utu.fi)\n\nCoffee and sandwich at 11:45\, first come first served!\n\n \;\n\nSix PhD researchers and early-career postdocs are w elcome to have a lunch in restaurant Mauno and discuss with Prof. Minucci after the seminar. This is a great possibility to learn hosting skills in friendly environment and create connections for future. Everyone is welcom e to join\, BioCity Turku will offer the lunch.\n\nIf you got interested\, please send an email to biocityturku@bioscience.fi\n\n \;\n\nProf. Mi nucci  has an outstanding reputation in the field of cancer research. Sin ce the beginning of his career\, he focused his research activities on the study of deregulation of chromatin structure/function in cancer\, aiming to the use of "potential drugs" interfering with chromatin modifying enzym es (histone deacetylases\, DNA methyltransferases\, histone demethylases) for clinical treatment of cancer patients. He contributed to several key d iscoveries in this area\, that have shaped the field of cancer epigenetics \, and the concept of epigenetic therapy of cancer. His practical interest in drug discovery and translation of basic research into application led him to be scientific co-founder of the Italian biotechnological and biopha rmaceutical holding company Genextra Spa.\n\n \;\n\nSelected publicati ons\n\nCazzoli R\, Romeo F\, Pallavicini I\, Peri S\, Romanenghi M\, Pére z-Valencia JA\, Hagag E\, Ferrucci F\, Elgendy M\, Vittorio O\, Pece S\, F oiani M\, Westermarck J\, Minucci S. 2023. Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition. Cell Rep. 2023 Jun 7\;42(6): 112616. doi: 10.1016/j.celrep.2023.112616\n\nMoretti S\, Abdel-Aziz AK\, C eccacci E\, Pallavicini I\, Santoro F\, de Thé H\, Minucci S. 2022. Co-ta rgeting leukemia-initiating cells and leukemia bulk leads to disease eradi cation. Leukemia. 2022 May\;36(5):1306-1312. doi: 10.1038/s41375-022-01530 -3\n\nNicosia L\, Boffo FL\, Ceccacci E\, Conforti F\, Pallavicini I\, Bed in F\, Ravasio R\, Massignani E\, Somervaille TCP\, Minucci S\, Bonaldi T. 2022. Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1 oncogenic functions in AML. Oncogene. 2022 Feb\;41(6):8 78-894. doi: 10.1038/s41388-021-02123-7\n\nRavasio R\, Ceccacci E\, Nicosi a L\, Hosseini A\, Rossi PL\, Barozzi I\, Fornasari L\, Zuffo RD\, Valente S\, Fioravanti R\, Mercurio C\, Varasi M\, Mattevi A\, Mai A\, Pavesi G\, Bonaldi T\, Minucci S. 2020. Targeting the scaffolding role of LSD1 (KDM1 A) poises acute myeloid leukemia cells for retinoic acid-induced different iation. Sci Adv. 2020 Apr 8\;6(15):eaax2746. doi: 10.1126/sciadv.aax2746\n \nElgendy M\, Cirò M\, Hosseini A\, Weiszmann J\, Mazzarella L\, Ferrari E\, Cazzoli R\, Curigliano G\, DeCensi A\, Bonanni B\, Budillon A\, Pelicc i PG\, Janssens V\, Ogris M\, Baccarini M\, Lanfrancone L\, Weckwerth W\, Foiani M\, Minucci S. 2019. Combination of Hypoglycemia and Metformin Impa irs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MC L-1 Axis. Cancer Cell. 2019 May 13\;35(5):798-815.e5. doi: 10.1016/j.ccell .2019.03.007\n\n \;\n\nGeneral information\n\n You can download and s ave all the spring 2024 FoS-seminars to your calendar from here: https://s eafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Registration is not needed\, part icipation list is circulated in the audience\n If you are a student and l ater wish to get a certificate of attendance from the Frontier of Science seminars\, print out the seminar diary and after the seminar ask the BioCi ty coordinator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Please note that any audio or video recording of the seminars is strictl y forbidden.\n Spring 2024 FoS image credits to Jenny Pessa: Transformed human breast epithelial HS578T cells (flattened)\, labelled with commercia l fluorescent antibodies. Image acquired on 3i CSU-W1 Spinning disk with 4 0x objective.\n\n \;\n\n \;\n\n \; ATTACH;FMTTYPE=image/jpeg:https://biocityturku.fi/wp-content/uploads/minuc ci-400.jpg CATEGORIES:Frontiers of Science END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20240331T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR