BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN BEGIN:VEVENT UID:283@biocityturku.fi DTSTART;TZID=Europe/Helsinki:20230427T120000 DTEND;TZID=Europe/Helsinki:20230427T130000 DTSTAMP:20231013T063916Z URL:https://biocityturku.fi/events/frontiers-of-science-prof-jason-sheltze r-2/ SUMMARY:CANCELLED: Frontiers of Science: Prof. Jason Sheltzer DESCRIPTION:\nCANCELLED\n\nSpring 2023 program\n\nProf. Jason Sheltzer\, Ya le School of Medicine\, USA\nMischaracterized anti-cancer agents and their true targets\nHost: Jukka Westermarck (jukwes@utu.fi)\n\nThe Sheltzer Lab studies the genetic changes that drive cancer progression and cause devel opmental disabilities. The group is particularly interested in a condition called aneuploidy – a state in which cells gain or lose whole chromosom es. Aneuploidy is found in more than 90% of human tumors and is the most c ommon cause of miscarriage and intellectual disability\, but its effects o n cell physiology are poorly understood. We apply a variety of complementa ry technologies\, including chromosome engineering\, CRISPR/Cas9 mutagenes is\, and single cell sequencing\, in order to develop new ways to model an euploidy and to better understand its cellular and organismal consequences . The genetic alterations that occur during tumorigenesis re-wire the unde rlying architecture of cancer cells and create certain cancer “dependenc ies”: genes and pathways that are required for cancer cell growth but th at are dispensable in normal tissue. Drugs that inhibit the function of a cancer dependency can serve as potent therapeutic agents. Using CRISPR/Cas 9\, the Sheltzer Lab is working to identify novel cancer dependencies\, an d to improve the characterization of the drugs that target them.\n\n \ ;\n\nSelected publications\n\nSchukken KM\, Sheltzer JM. 2022. Extensive p rotein dosage compensation in aneuploid human cancers. Genome Res. 32:1254 -1270\n\nSmith JC\, Sheltzer JM. 2022. Genome-wide identification and anal ysis of prognostic features in human cancers. Cell Rep. 38:110569\n\nChen WC\, Zhou J\, Sheltzer JM\, Kinney JB\, McCandlish DM. 2021. Field-theoret ic density estimation for biological sequence space with applications to 5 ' splice site diversity and aneuploidy in cancer. Proc Natl Acad Sci U S A . 118:e2025782118\n\nVasudevan A\, Schukken KM\, Sausville EL\, Girish V\, Adebambo OA\, Sheltzer JM. 2021. Aneuploidy as a promoter and suppressor of malignant growth. Nat Rev Cancer. 21:89-103\n\nLin A\, Sheltzer JM. 202 0. Discovering and validating cancer genetic dependencies: approaches and pitfalls. Nat Rev Genet. 21:671-682\n\nSmith JC\, Sheltzer JM. 2018. Syste matic identification of mutations and copy number alterations associated w ith cancer patient prognosis. Elife. 7:e39217\n\n \;\n\nGeneral inform ation\n\n You can download all spring 2023 FoS-seminars in your calendar from here: https://seafile.utu.fi/d/4a0b831f23ef420786b0/\n Registration is not needed for the on-site seminars\n Participation list is circulated in the audience\n If you are a student and later wish to get a certifica te of attendance from the Frontier of Science seminars\, please print out this seminar diary and after the seminar ask the BioCity coordinator to si gn it\n Please note that any audio or video recording of the seminars is strictly forbidden.\n\n \; CATEGORIES:BiocityTurku events,Frontiers of Science LOCATION:#_LOCATIONNAME\, #_LOCATIONFULLLINE\, #_LOCATIONCOUNTRY X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=#_LOCATIONFULLLINE\, #_LOCA TIONCOUNTRY;X-APPLE-RADIUS=100;X-TITLE=#_LOCATIONNAME:geo:0,0 END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20230326T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR