BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.3.1//EN BEGIN:VEVENT UID:543@biocityturku.fi DTSTART;TZID=Europe/Helsinki:20240926T120000 DTEND;TZID=Europe/Helsinki:20240926T130000 DTSTAMP:20240612T120753Z URL:https://biocityturku.fi/events/frontiers-of-science-prof-james-c-coste llo/ SUMMARY:Frontiers of Science: Prof. James C. Costello DESCRIPTION:September 26th at 12:00\nOnsite event\nin Arje Scheinin auditor ium\, Dentalia\n\nProf. James C. Costello\, University of Colorado\, USA\n A novel mechanism of chemotherapy resistance by the regulation of volume r egulated anion channels\nHost: Teemu Daniel Laajala (teelaa@utu.fi)\n\nCof fee and sandwich at 11:45\, first come first served!\n\n \;\n\nSix PhD researchers and early-career postdocs are welcome to have a lunch and dis cuss with Prof. Costello after the seminar. This is a great possibility to learn hosting skills in friendly environment and create connections for f uture. Everyone is welcome to join\, BioCity Turku will offer the lunch.\n \nIf you got interested\, please send an email to biocityturku@bioscience. fi\n\n \;\n\nToday\, we have the ability to take a snapshot of the tra nscriptional activity of genes\, identify mutations\, and quantify the pro tein and metabolite content of cells.  All of these measurements can be m ade at a systems-wide level. These data present the potential to greatly i mprove our ability to characterize and treat disease\; however\, the rate of data production is far outpacing our ability to analyze\, interpret\, a nd ultimately build predictive tools in medicine.  Costello lab takes a c omplementary dry and wet lab approach to close the gap between raw data an d biological understanding. Their dry lab research focuses on developing a nd implementing computational tools that distill this large pool of genome -scale data into actionable hypothesis. Costello wet lab research brings t he computational modeling to the bench where the aim is to characterize th e genomic components that contribute to drug mode of action in cancer biol ogy.\n\n \;\n\nSelected publications\n\nHughes CJ\, Fields KM\, Danis EP\, Hsu JY\, Neelakantan D\, Vincent MY\, Gustafson AL\, Oliphant MJ\, Sr eekanth V\, Zaberezhnyy V\, Costello JC\, Jedlicka P\, Ford HL. 2023. SIX1 and EWS/FLI1 co-regulate an anti-metastatic gene network in Ewing Sarcoma . Nat Commun. 2023 14(1):4357. doi: 10.1038/s41467-023-39945-w.\n\nde Jong FC\, Laajala TD\, Hoedemaeker RF\, Jordan KR\, van der Made ACJ\, Boevé ER\, van der Schoot DKE\, Nieuwkamer B\, Janssen EAM\, Mahmoudi T\, Boorma ns JL\, Theodorescu D\, Costello JC\, Zuiverloon TCM. 2023. Non-muscle-inv asive bladder cancer molecular subtypes predict differential response to i ntravesical Bacillus Calmette-Guérin. Sci Transl Med. 15(697):eabn4118. d oi: 10.1126/scitranslmed.abn4118.\n\nSun D\, Nguyen TM\, Allaway RJ\, Wang J\, Chung V\, Yu TV\, Mason M\, Dimitrovsky I\, Ericson L\, Li H\, Guan Y \, Israel A\, Olar A\, Pataki BA\, Stolovitzky G\, Guinney J\, Gulko PS\, Frazier MB\, Chen JY\, Costello JC\, Bridges SL Jr\; RA2-DREAM Challenge C ommunity. 2022. A Crowdsourcing Approach to Develop Machine Learning Model s to Quantify Radiographic Joint Damage in Rheumatoid Arthritis. JAMA Netw Open. 25(8):e2227423. doi: 10.1001/jamanetworkopen.2022.27423.\n\nTarca A L\, Pataki BÁ\, Romero R\, Sirota M\, Guan Y\, Kutum R\, Gomez-Lopez N\, Done B\, Bhatti G\, Yu T\, Andreoletti G\, Chaiworapongsa T\; DREAM Preter m Birth Prediction Challenge Consortium\; Hassan SS\, Hsu CD\, Aghaeepour N\, Stolovitzky G\, Csabai I\, Costello JC. 2021. Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth. Cell Rep Med. 2(6):100323. doi: 10.1016/j.xcrm.2021.100323.\n\nGree ne CS\, Costello JC. 2020. Biologically Informed Neural Networks Predict D rug Responses. Cancer Cell. 38(5):613-615. doi: 10.1016/j.ccell.2020.10.01 4.\n\n \;\n\nGeneral information\n\n You can download and save all th e autumn 2024 FoS-seminars to your calendar from here: https://seafile.utu .fi/d/44a70f80ac1e46a9ad0a/\n Registration is not needed\, participation list is circulated in the audience\n If you are a student and later wish to get a certificate of attendance from the Frontier of Science seminars\, print out the seminar diary and after the seminar ask the BioCity coordin ator to sign it https://seafile.utu.fi/d/44a70f80ac1e46a9ad0a/\n Please n ote that any audio or video recording of the seminars is strictly forbidde n.\n Autumn 2024 FoS image credits to Mia Åstrand: Details of the Bacter oides fragilis VgrG protein (PDB ID: 8GRA). Image created in the PyMOL Mol ecular Graphics System\, Version 2.5 Schrödinger\, LLC.\n\n \;\n\n&nb sp\; ATTACH;FMTTYPE=image/jpeg:https://biocityturku.fi/wp-content/uploads/coste llo-400.jpg CATEGORIES:Frontiers of Science END:VEVENT BEGIN:VTIMEZONE TZID:Europe/Helsinki X-LIC-LOCATION:Europe/Helsinki BEGIN:DAYLIGHT DTSTART:20240331T040000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:EEST END:DAYLIGHT END:VTIMEZONE END:VCALENDAR